AZD1386

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Synonyms
Status
Molecule Category Free-form
UNII 210323T9CP

Structure

InChI Key DXDVSYALLVVBOV-UHFFFAOYSA-N
Smiles Cc1cc(Cl)cc2c1N(Cc1cccc(C(F)(F)F)c1)C(=O)C21NC(=O)NC1=O
InChI
InChI=1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H13ClF3N3O3
Molecular Weight 423.78
AlogP 3.25
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 78.51
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 29.0

Pharmacology

Mechanism of Action Action Reference
Vanilloid receptor antagonist ANTAGONIST PubMed

Target Conservation

Protein: Vanilloid receptor
Description: Transient receptor potential cation channel subfamily V member 1
Organism : Homo sapiens
Q8NER1 ENSG00000196689

Cross References

Resources Reference
ChEMBL CHEMBL3545039
FDA SRS 210323T9CP
Guide to Pharmacology 7820
SureChEMBL SCHEMBL4257077
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