EcoDrugPlus


Synonyms	Civamide Zucapsaicin
Status
Molecule Category	Free-form
ATC	M02AB02
UNII	15OX67P384

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SubStructure

Threshold (%) >= 70


InChI Key	YKPUWZUDDOIDPM-VURMDHGXSA-N
Smiles	COc1cc(CNC(=O)CCCC/C=C\C(C)C)ccc1O
InChI	InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6-

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H27NO3
Molecular Weight	305.42
AlogP	3.79
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	9.0
Polar Surface Area	58.56
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	22.0

Mechanism of Action	Action	Reference
Vanilloid receptor agonist	AGONIST	EMA PubMed Other PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Transient receptor potential channel	28.2	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	28.2	-	-	-	-
Mus musculus	-	-	-	-	79.5

Target Conservation


Protein: Vanilloid receptor Description: Transient receptor potential cation channel subfamily V member 1 Organism : Homo sapiens Q8NER1 ENSG00000196689

Cross References

Resources	Reference
ChEBI	135952
ChEMBL	CHEMBL313971
DrugBank	DB09120
DrugCentral	4342
FDA SRS	15OX67P384
PubChem	1548942
SureChEMBL	SCHEMBL41210
ZINC	ZINC000004468952

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ZUCAPSAICIN

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References