VS-4718

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Synonyms
Status
Molecule Category Free-form
UNII L2BD0MW4OL

Structure

InChI Key IGUBBWJDMLCRIK-UHFFFAOYSA-N
Smiles CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F
InChI
InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)

Pharmacology

Mechanism of Action Action Reference
Focal adhesion kinase 1 inhibitor INHIBITOR PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase JNK subfamily
- 120-160 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Fak family
- 1.5-1.5 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 0.3-930 - - -

Target Conservation

Protein: Focal adhesion kinase 1
Description: Focal adhesion kinase 1
Organism : Homo sapiens
Q05397 ENSG00000169398

Cross References

Resources Reference
ChEMBL CHEMBL3544933
FDA SRS L2BD0MW4OL
Guide to Pharmacology 8742
PubChem 25073775
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