EcoDrugPlus


Synonyms	7162 RP 7162-RP IL 6001 IL-6001 Surmontil Trimeproprimine Trimipramine
Status
Molecule Category	Free-form
ATC	N06AA06
UNII	6S082C9NDT
EPA CompTox	DTXSID8023715


InChI Key	ZSCDBOWYZJWBIY-UHFFFAOYSA-N
Smiles	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21
InChI	InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3

Property Name	Value
Molecular Formula	C20H26N2
Molecular Weight	294.44
AlogP	4.12
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	6.48
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	22.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	77.2

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	77.2

Resources	Reference
ChEBI	9738
ChEMBL	CHEMBL644
DrugBank	DB00726
DrugCentral	2758
FDA SRS	6S082C9NDT
Human Metabolome Database	HMDB0014864
Guide to Pharmacology	7317
PharmGKB	PA451791
PubChem	5584
SureChEMBL	SCHEMBL35144

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TRIMIPRAMINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References