TEZAMPANEL

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Synonyms
Status
Molecule Category Free-form
UNII GA36S2O9C2

Structure

InChI Key ZXFRFPSZAKNPQQ-YTWAJWBKSA-N
Smiles O=C(O)[C@@H]1C[C@H]2C[C@@H](CCc3nn[nH]n3)CC[C@H]2CN1
InChI
InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H21N5O2
Molecular Weight 279.34
AlogP 0.61
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 103.79
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 20.0

Pharmacology

Mechanism of Action Action Reference
Glutamate receptor ionotropic AMPA antagonist ANTAGONIST PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor AMPA receptor
- 230-600 - - -
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor Kainate receptor
- 230-500 - - 60
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
- - - - 60
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 500-500 - - -
Rattus norvegicus
- 230-600 - 680 -
frog
- 233 - - -

Target Conservation

Protein: Glutamate receptor ionotropic kainate
Description: Glutamate receptor ionotropic, kainate 1
Organism : Homo sapiens
P39086 ENSG00000171189
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 1
Organism : Homo sapiens
P42261 ENSG00000155511
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 2
Organism : Homo sapiens
P42262 ENSG00000120251
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 3
Organism : Homo sapiens
P42263 ENSG00000125675
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 4
Organism : Homo sapiens
P48058 ENSG00000152578
Protein: Glutamate receptor ionotropic kainate
Description: Glutamate receptor ionotropic, kainate 2
Organism : Homo sapiens
Q13002 ENSG00000164418
Protein: Glutamate receptor ionotropic kainate
Description: Glutamate receptor ionotropic, kainate 3
Organism : Homo sapiens
Q13003 ENSG00000163873
Protein: Glutamate receptor ionotropic kainate
Description: Glutamate receptor ionotropic, kainate 4
Organism : Homo sapiens
Q16099 ENSG00000149403
Protein: Glutamate receptor ionotropic kainate
Description: Glutamate receptor ionotropic, kainate 5
Organism : Homo sapiens
Q16478 ENSG00000105737

Related Entries

Cross References

Resources Reference
ChEMBL CHEMBL14935
DrugBank DB06354
FDA SRS GA36S2O9C2
Guide to Pharmacology 4245
PubChem 23725095
SureChEMBL SCHEMBL1649338
ZINC ZINC000005134714
ChEMBL CHEMBL3989703
FDA SRS 6XN50U405Y
Guide to Pharmacology 4245
PubChem 23725095
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