SX-682

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Search structure


Synonyms	Sx-682
Status
Molecule Category	Free-form
UNII	H5212R2DPM

Structure


InChI Key	SDUDZBCEHIZMFZ-UHFFFAOYSA-N
Smiles	O=C(Nc1ccc(F)cc1)c1cnc(SCc2cc(OC(F)(F)F)ccc2B(O)O)nc1
InChI	InChI=1S/C19H14BF4N3O4S/c21-13-1-3-14(4-2-13)27-17(28)12-8-25-18(26-9-12)32-10-11-7-15(31-19(22,23)24)5-6-16(11)20(29)30/h1-9,29-30H,10H2,(H,27,28)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H14BF4N3O4S
Molecular Weight	467.21

Pharmacology

Mechanism of Action	Action	Reference
Interleukin-8 receptors, CXCR1/CXCR2 inhibitor	INHIBITOR	ClinicalTrials PubMed

Target Conservation


Protein: Interleukin-8 receptors, CXCR1/CXCR2 Description: C-X-C chemokine receptor type 1 Organism : Homo sapiens P25024 ENSG00000163464











Protein: Interleukin-8 receptors, CXCR1/CXCR2 Description: C-X-C chemokine receptor type 2 Organism : Homo sapiens P25025 ENSG00000180871

Cross References

Resources	Reference
ChEMBL	CHEMBL4297480
FDA SRS	H5212R2DPM
Guide to Pharmacology	10165
PubChem	90467234
SureChEMBL	SCHEMBL16436044

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025