EcoDrugPlus


Synonyms	Evrysdi RG-7916 RG7916 RO-7034067 RO7034067 Risdiplam
Status
Molecule Category	Free-form
ATC	M09AX10
UNII	76RS4S2ET1

Synonyms

Evrysdi

RG-7916

RG7916

RO-7034067

RO7034067

Risdiplam

Status

Molecule Category

Free-form

ATC

M09AX10

UNII

76RS4S2ET1


InChI Key	ASKZRYGFUPSJPN-UHFFFAOYSA-N
Smiles	Cc1cn2nc(-c3cc(=O)n4cc(N5CCNC6(CC6)C5)ccc4n3)cc(C)c2n1
InChI	InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3

InChI Key

ASKZRYGFUPSJPN-UHFFFAOYSA-N

Smiles

Cc1cn2nc(-c3cc(=O)n4cc(N5CCNC6(CC6)C5)ccc4n3)cc(C)c2n1

InChI

InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3

Property Name	Value
Molecular Formula	C22H23N7O
Molecular Weight	401.47
AlogP	1.96
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	79.83
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	30.0

Property Name

Value

Molecular Formula

C22H23N7O

Molecular Weight

401.47

AlogP

1.96

Hydrogen Bond Acceptor

8.0

Hydrogen Bond Donor

1.0

Number of Rotational Bond

2.0

Polar Surface Area

79.83

Molecular species

BASE

Aromatic Rings

4.0

Heavy Atoms

30.0

Mechanism of Action	Action	Reference
SMN2 pre-mRNA positive modulator	POSITIVE MODULATOR	FDA

Mechanism of Action

Action

Reference

SMN2 pre-mRNA positive modulator

POSITIVE MODULATOR

FDA

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	67	113	-	-	-
Macaca fascicularis	-	155	-	-	-

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Homo sapiens

113

Macaca fascicularis

155

Resources	Reference
ChEMBL	CHEMBL4297528
DrugBank	DB15305
FDA SRS	76RS4S2ET1
Guide to Pharmacology	11170
PubChem	118513932
SureChEMBL	SCHEMBL17260852

Resources

Reference

ChEMBL

CHEMBL4297528

DrugBank

DB15305

FDA SRS

76RS4S2ET1

Guide to Pharmacology

11170

PubChem

118513932

SureChEMBL

SCHEMBL17260852

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

RISDIPLAM

Structure

Physicochemical Descriptors

Pharmacology

Cross References