RADIPRODIL

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Synonyms
Status
Molecule Category Free-form
UNII 5XGC17ZKUF

Structure

InChI Key GKGRZLGAQZPEHO-UHFFFAOYSA-N
Smiles O=C(Nc1ccc2nc(O)oc2c1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1
InChI
InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H20FN3O4
Molecular Weight 397.41
AlogP 2.68
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 95.41
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 29.0

Pharmacology

Mechanism of Action Action Reference
Glutamate NMDA receptor; GRIN1/GRIN2B antagonist ANTAGONIST
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
- 3.162-69.91 - - 5-10.14
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Mus musculus
- 3.162-3.162 - - -
Rattus norvegicus
- 31.62-31.62 - - -

Target Conservation

Protein: Glutamate NMDA receptor; GRIN1/GRIN2B
Description: Glutamate receptor ionotropic, NMDA 1
Organism : Homo sapiens
Q05586 ENSG00000176884
Protein: Glutamate NMDA receptor; GRIN1/GRIN2B
Description: Glutamate receptor ionotropic, NMDA 2B
Organism : Homo sapiens
Q13224 ENSG00000273079

Cross References

Resources Reference
ChEMBL CHEMBL182066
DrugBank DB12260
FDA SRS 5XGC17ZKUF
PubChem 10200813
SureChEMBL SCHEMBL99256
ZINC ZINC000028363953
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