QUININE

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Synonyms
Status
Molecule Category Free-form
ATC P01BC01
UNII A7V27PHC7A
EPA CompTox DTXSID0044280

Structure

InChI Key LOUPRKONTZGTKE-WZBLMQSHSA-N
Smiles C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12
InChI
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H24N2O2
Molecular Weight 324.42
AlogP 3.17
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 45.59
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0
Assay Description Organism Bioactivity Reference
Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiae Rattus norvegicus 94.0 nM
Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line Homo sapiens 610.0 nM
In vitro antimalarial activity against Plasmodium falciparum W-2 Indochina Plasmodium falciparum 0.059 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum D6 (Sierra Leone) Plasmodium falciparum 0.00361 ug.mL-1
Inhibitory concentration against Plasmodium falciparum D6 infected erythrocytes Plasmodium falciparum 48.0 nM
Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes Plasmodium falciparum 100.0 nM
Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2. Plasmodium falciparum 380.0 nM
Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay Plasmodium falciparum 380.0 nM
Inhibitory activity against Plasmodium falciparum D6 Plasmodium falciparum 0.1596 ug.mL-1
Inhibitory activity against Plasmodium falciparum K1 Plasmodium falciparum 0.0996 ug.mL-1
Inhibitory activity against Plasmodium falciparum NF54 Plasmodium falciparum 0.00908 ug.mL-1
Inhibitory activity against Plasmodium falciparum W2 Plasmodium falciparum 0.1499 ug.mL-1
Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes Plasmodium falciparum 380.0 nM
Inhibitory concentration against ferriprotoporphyrin in biomineralisation (FBIT) Plasmodium falciparum 80.0 ug.mL-1
Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes Plasmodium falciparum 96.0 nM
Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes Plasmodium falciparum 380.0 nM
In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake Plasmodium falciparum 370.0 nM
In vitro inhibition of parasite development of Plasmodium falciparum W2 in human erythrocytes Plasmodium falciparum 120.0 nM
Compound was evaluated for its antimalarial activity in vitro on Plasmodium falciparum Plasmodium falciparum 0.17 ug.mL-1
In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 Plasmodium falciparum 110.0 nM
In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 Plasmodium falciparum 110.0 nM
In vitro antimalarial activity against Plasmodium falciparum FCR3 Plasmodium falciparum 110.0 nM
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM Cavia porcellus 69.3 %
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 Plasmodium falciparum 110.0 nM
Inhibition of Plasmodium falciparum in HRP2 ELISA Plasmodium falciparum 0.06436 ug.mL-1
Inhibition of Plasmodium falciparum AZ10011003 isolate in HRP2 ELISA Plasmodium falciparum 0.1233 ug.mL-1
Inhibition of Plasmodium falciparum AZ10011008 isolate in HRP2 ELISA Plasmodium falciparum 0.08282 ug.mL-1
Inhibition of Plasmodium falciparum AZ10011017 isolate in HRP2 ELISA Plasmodium falciparum 0.05829 ug.mL-1
Inhibition of Plasmodium falciparum AZ10011022 isolate in HRP2 ELISA Plasmodium falciparum 0.1164 ug.mL-1
Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay Plasmodium falciparum 66.52 nM
Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay Plasmodium falciparum 69.19 nM
Growth inhibition of Plasmodium falciparum as reduced [3H]hypoxanthine incorporation Plasmodium falciparum 62.77 nM
Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by pLDH assay Plasmodium falciparum 149.0 nM
Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by pLDH assay Plasmodium falciparum 73.5 nM
Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by pLDH assay Plasmodium falciparum 96.8 nM
Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by pLDH assay Plasmodium falciparum 75.3 nM
Antimalarial activity against Plasmodium falciparum D6 in MSF assay Plasmodium falciparum 11.0 nM
Antimalarial activity against Plasmodium falciparum W2 in MSF assay Plasmodium falciparum 60.0 nM
In vitro antimalarial activity against Plasmodium falciparum D6 after 72 hrs in SYBR green fluorescence assay Plasmodium falciparum 0.0158 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum W2 after 72 hrs in SYBR green fluorescence assay Plasmodium falciparum 0.1675 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum D6 after 72 hrs by SYBR green fluorescence assay Plasmodium falciparum 0.0113 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green fluorescence assay Plasmodium falciparum 0.1285 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum D6 after 72 hrs in SYBR green fluorescence assay Plasmodium falciparum 0.0149 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum W2 after 72 hrs in SYBR green fluorescence assay Plasmodium falciparum 0.1623 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum D6 after 72 hrs in SYBR green fluorescence assay Plasmodium falciparum 0.0119 ug.mL-1
In vitro antimalarial activity against Plasmodium falciparum W2 after 72 hrs in SYBR green fluorescence assay Plasmodium falciparum 0.0923 ug.mL-1
Antimalarial activity against Plasmodium falciparum D6 as reduced [3H]hypoxanthine uptake after 72 hrs Plasmodium falciparum 0.005 ug.mL-1
Antimalarial activity against Plasmodium falciparum W2 as reduced [3H]hypoxanthine uptake after 72 hrs Plasmodium falciparum 0.036 ug.mL-1
Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina W2 after 24 to 60 hrs by [G-H3]hypoxanthine uptake Plasmodium falciparum 0.0686 ug.mL-1
Antimalarial activity against mefloquine-resistant Plasmodium falciparum D6 (Sierra Leone) after 24 to 60 hrs by [G-H3]hypoxanthine uptake Plasmodium falciparum 0.012 ug.mL-1
Antimalarial activity against Plasmodium falciparum D6 in human erythrocytes after 24 hrs by [3H]hypoxanthine uptake Plasmodium falciparum D6 0.0194 ug.mL-1
Antimalarial activity against Plasmodium falciparum W2 in human erythrocytes after 24 hrs by [3H]hypoxanthine uptake Plasmodium falciparum 0.1144 ug.mL-1
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 as [3H]hypoxanthine uptake Plasmodium falciparum D6 0.0157 ug.mL-1
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as [3H]hypoxanthine uptake Plasmodium falciparum 0.0388 ug.mL-1
Cytotoxicity against human KB cells Homo sapiens 20.0 ug.mL-1
Antiplasmodial activity against Plasmodium falciparum D6 Plasmodium falciparum D6 0.0111 ug.mL-1
Antiplasmodial activity against Plasmodium falciparum W2 Plasmodium falciparum 0.0546 ug.mL-1
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 Plasmodium falciparum D6 0.0196 ug.mL-1
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Plasmodium falciparum 0.102 ug.mL-1
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake Plasmodium falciparum 269.0 nM
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake Plasmodium falciparum 413.0 nM
Cytotoxicity against human KB cells Homo sapiens 20.0 ug.mL-1
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 Plasmodium falciparum D6 0.0102 ug.mL-1
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Plasmodium falciparum 0.0238 ug.mL-1
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by [3H]hypoxanthine uptake Plasmodium falciparum D6 0.009 ug.mL-1
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake Plasmodium falciparum 200.0 nM
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake Plasmodium falciparum 413.0 nM
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake Plasmodium falciparum 269.0 nM
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by [3H]hypoxanthine uptake Plasmodium falciparum 0.041 ug.mL-1
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs Plasmodium falciparum D6 23.38 nM
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs Plasmodium falciparum 250.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 Plasmodium falciparum D6 0.011 ug.mL-1
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Plasmodium falciparum 0.029 ug.mL-1
Antimalarial activity after 48 hrs against Plasmodium falciparum W2 by [3H]hypoxanthine uptake Plasmodium falciparum 67.0 ug.mL-1
Antimalarial activity after 48 hrs against Plasmodium falciparum D6 by [3H]hypoxanthine uptake Plasmodium falciparum D6 25.0 ug.mL-1
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy Homo sapiens 60.2 %
Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake Plasmodium falciparum K1 81.0 nM
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes by [3H]hypoxanthine uptake Plasmodium falciparum D6 0.0176 ug.mL-1
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes by [3H]hypoxanthine uptake Plasmodium falciparum 0.102 ug.mL-1
Antiplasmodial activity against Plasmodium falciparum K1 infected human erythrocytes by [3H]hypoxanthine uptake Plasmodium falciparum K1 0.0352 ug.mL-1
Antimalarial activity against Plasmodium falciparum D6 by [3H]hypoxanthine uptake Plasmodium falciparum D6 0.0148 ug.mL-1
Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake Plasmodium falciparum 0.0349 ug.mL-1
Cytotoxicity against human KB cells Homo sapiens 20.0 ug.mL-1
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCM29 by SYBR green assay Plasmodium falciparum 220.0 nM
Antimalarial activity against Plasmodium falciparum K1 Plasmodium falciparum K1 12.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum 428.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum 314.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum 543.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum 571.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum FCR-3/Gambia 650.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum 5.8 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay Plasmodium falciparum 6.7 nM
Antimalarial activity against cycloguanil-resistant Plasmodium falciparum CDC1 assessed as inhibition of ring stage parasitaemia after 48 hrs by Giemsa staining Plasmodium falciparum 0.04 ug.mL-1
Antimalarial activity against Plasmodium falciparum Nigerian assessed as [3H]hypoxanthine uptake after 48 hrs by liquid scintillation counting Plasmodium falciparum 180.0 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 3D7 103.8 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum D6 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum D6 61.8 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 8425 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 130.3 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 421.7 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 530.9 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 626.6 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 688.7 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 665.3 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 683.9 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 619.4 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 495.5 nM
Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs Plasmodium falciparum 543.3 nM
Antimicrobial activity against Plasmodium falciparum by ELISA Plasmodium falciparum 94.4 nM
Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA Plasmodium falciparum 490.8 nM
Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA Plasmodium falciparum 106.9 nM
Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA Plasmodium falciparum HB3 236.1 nM
Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA Plasmodium falciparum K1 276.0 nM
Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA Plasmodium falciparum 15.4 nM
Antimalarial activity against early trophozoite-stage Plasmodium falciparum 3D7 infected in erythrocyte assessed as reduction in parasite hemoglobin content at 5 times IC50 after 8 hrs Plasmodium falciparum 84.0 %
Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum 120.0 nM
Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum 320.0 nM
Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum HB3 140.0 nM
Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum HB3 160.0 nM
Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum 31.0 nM
Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum 80.0 nM
Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum 7G8 110.0 nM
Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum 7G8 130.0 nM
Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum 36.0 nM
Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum 130.0 nM
Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum D10 80.0 nM
Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum D10 40.0 nM
Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 1536-well format based SYBR green assay Plasmodium falciparum 160.0 nM
Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 96-well format based SYBR green assay Plasmodium falciparum 300.0 nM
Antimalarial activity against Plasmodium falciparum isolate AK183 Plasmodium falciparum 73.9 nM
Antimalarial activity against Plasmodium falciparum isolate 8885 Plasmodium falciparum 78.2 nM
Antimalarial activity against Plasmodium falciparum isolate 9067 Plasmodium falciparum 80.1 nM
Antimalarial activity against Plasmodium falciparum isolate AK018 Plasmodium falciparum 141.1 nM
Antimalarial activity against Plasmodium falciparum isolate AK150 D-42 Plasmodium falciparum 91.6 nM
Antimalarial activity against Plasmodium falciparum isolate AK144 Plasmodium falciparum 145.8 nM
Antimalarial activity against Plasmodium falciparum isolate AK062 Plasmodium falciparum 181.5 nM
Antimalarial activity against Plasmodium falciparum isolate AK152 D-56 Plasmodium falciparum 207.7 nM
Antimalarial activity against Plasmodium falciparum isolate AK167 Plasmodium falciparum 227.0 nM
Antimalarial activity against Plasmodium falciparum isolate AK222 Plasmodium falciparum 210.5 nM
Antimalarial activity against Plasmodium falciparum isolate AK158 Plasmodium falciparum 234.0 nM
Antimalarial activity against Plasmodium falciparum isolate AK121 Plasmodium falciparum 270.2 nM
Antimalarial activity against Plasmodium falciparum isolate AK249 Plasmodium falciparum 270.4 nM
Antimalarial activity against Plasmodium falciparum isolate AK150 D-0 Plasmodium falciparum 296.6 nM
Antimalarial activity against Plasmodium falciparum isolate AK227 Plasmodium falciparum 495.3 nM
Antimalarial activity against Plasmodium falciparum isolate CDA-1553 Plasmodium falciparum 333.3 nM
Antimalarial activity against Plasmodium falciparum isolate AK182 Plasmodium falciparum 549.2 nM
Antimalarial activity against Plasmodium falciparum isolate AK127 Plasmodium falciparum 569.5 nM
Antimalarial activity against Plasmodium falciparum 3D7 Plasmodium falciparum 27.1 nM
Antimalarial activity against Plasmodium falciparum isolate 6816 Plasmodium falciparum 73.3 nM
Antimalarial activity against Plasmodium falciparum isolate 8966 Plasmodium falciparum 55.8 nM
Antimalarial activity against Plasmodium falciparum isolate AK033 D-49 Plasmodium falciparum 54.1 nM
Antimalarial activity against Plasmodium falciparum isolate AK022D-0 Plasmodium falciparum 42.4 nM
Antimalarial activity against Plasmodium falciparum isolate 9070 Plasmodium falciparum 41.5 nM
Antimalarial activity against Plasmodium falciparum isolate 8977 Plasmodium falciparum 35.9 nM
Antimalarial activity against Plasmodium falciparum isolate AK033 D-0 Plasmodium falciparum 32.8 nM
Antimalarial activity against Plasmodium falciparum isolate 8968 Plasmodium falciparum 30.6 nM
Antimalarial activity against Plasmodium falciparum isolate 8948 Plasmodium falciparum 27.8 nM
Antimalarial activity against Plasmodium falciparum isolate AK022 D-28 Plasmodium falciparum 22.0 nM
Antimalarial activity against Plasmodium falciparum isolate 8973 Plasmodium falciparum 20.0 nM
Antimalarial activity against Plasmodium falciparum harboring 1 DNNND repeat Plasmodium falciparum 182.0 nM
Antimalarial activity against Plasmodium falciparum harboring 1 DDNHNDHHNND repeat Plasmodium falciparum 141.0 nM
Antimalarial activity against Plasmodium falciparum harboring 2 DNNND repeat Plasmodium falciparum 227.0 nM
Antimalarial activity against Plasmodium falciparum harboring 3 DNNND repeat Plasmodium falciparum 45.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfcrt gene Plasmodium falciparum 142.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfcrt-76 mutant gene Plasmodium falciparum 164.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfmdr1 gene Plasmodium falciparum 208.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfmdr1-86 mutant gene Plasmodium falciparum 74.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfmdr1 gene with 2 DNNND repeat Plasmodium falciparum 92.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfmdr1-86 mutant gene with 2 DNNND repeat Plasmodium falciparum 249.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfcrt gene with 2 DNNND repeat Plasmodium falciparum 211.0 nM
Antimalarial activity against Plasmodium falciparum harboring pfcrt-76 mutant gene with 2 DNNND repeat Plasmodium falciparum 234.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 9881 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 57.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 10354 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 58.0 nM
Antimicrobial activity against Plasmodium falciparum D6 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 62.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 16332 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 83.0 nM
Antimicrobial activity against Plasmodium falciparum 3D7 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 128.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 8425 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 148.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 16116 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 204.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 10500 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 210.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 10336 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 271.0 nM
Antimicrobial activity against Plasmodium falciparum FCR3 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 334.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 31 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 371.0 nM
Antimicrobial activity against Plasmodium falciparum IMT Vol harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 421.0 nM
Antimicrobial activity against Plasmodium falciparum IMT 6311 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 453.0 nM
Antimicrobial activity against Plasmodium falciparum IMT Bres harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 500.0 nM
Antimicrobial activity against Plasmodium falciparum IMT L1 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 575.0 nM
Antimicrobial activity against Plasmodium falciparum FCM29 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 580.0 nM
Antimicrobial activity against Plasmodium falciparum IMT K2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 599.0 nM
Antimicrobial activity against Plasmodium falciparum IMT A4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 605.0 nM
Antimicrobial activity against Plasmodium falciparum PA harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 625.0 nM
Antimicrobial activity against Plasmodium falciparum W2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 686.0 nM
Antimicrobial activity against Plasmodium falciparum ms4760-2 assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 178.0 nM
Antimicrobial activity against Plasmodium falciparum ms4760-3 assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 178.0 nM
Antimicrobial activity against Plasmodium falciparum ms4760-6 assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 582.0 nM
Antimicrobial activity against Plasmodium falciparum ms4760-7 assessed as growth inhibition after 48 hrs by scintillation counting Plasmodium falciparum 764.0 nM
Antimicrobial activity against Plasmodium falciparum harboring CVMNT genotype after 72 hrs by SYBR green I assay Plasmodium falciparum 66.0 nM
Antimicrobial activity against Plasmodium falciparum harboring SVMNT genotype after 72 hrs by SYBR green I assay Plasmodium falciparum 70.0 nM
Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum HB3 48.0 nM
Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay Plasmodium falciparum VS/1 133.0 nM
Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay Plasmodium falciparum 105.68 nM
Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay Plasmodium falciparum 53.7 nM
Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 134.0 nM
Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 670.0 nM
Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 48.0 nM
Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 538.0 nM
Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 650.0 nM
Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 571.0 nM
Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum HB3 109.0 nM
Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 135.0 nM
Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 604.0 nM
Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 322.0 nM
Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 543.0 nM
Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 272.0 nM
Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 138.0 nM
Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 270.0 nM
Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 290.0 nM
Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 118.0 nM
Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 314.0 nM
Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 240.0 nM
Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 969.0 nM
Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 607.0 nM
Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 953.0 nM
Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 543.0 nM
Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter Plasmodium falciparum 428.0 nM
Antimicrobial activity against Plasmodium falciparum F07-7 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 456.0 nM
Antimicrobial activity against Plasmodium falciparum F07-10 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 306.0 nM
Antimicrobial activity against Plasmodium falciparum F07-23 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 447.0 nM
Antimicrobial activity against Plasmodium falciparum F07-50 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 204.0 nM
Antimicrobial activity against Plasmodium falciparum F07-59 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 197.0 nM
Antimicrobial activity against Plasmodium falciparum F08B53 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 468.0 nM
Antimicrobial activity against Plasmodium falciparum F09N1 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 191.0 nM
Antimicrobial activity against Plasmodium falciparum F09N18 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 284.0 nM
Antimicrobial activity against Plasmodium falciparum F07-13 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 365.0 nM
Antimicrobial activity against Plasmodium falciparum F09A54 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 243.0 nM
Antimicrobial activity against Plasmodium falciparum F09A55 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 149.0 nM
Antimicrobial activity against Plasmodium falciparum F09A9 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 562.0 nM
Antimicrobial activity against Plasmodium falciparum F09N72 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 500.0 nM
Antimicrobial activity against Plasmodium falciparum F07-3 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 875.0 nM
Antimicrobial activity against Plasmodium falciparum F07-9 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 321.0 nM
Antimicrobial activity against Plasmodium falciparum F07-11 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 629.0 nM
Antimicrobial activity against Plasmodium falciparum F07-46 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 894.0 nM
Antimicrobial activity against Plasmodium falciparum F07-56 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 427.0 nM
Antimicrobial activity against Plasmodium falciparum F08B32 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 302.0 nM
Antimicrobial activity against Plasmodium falciparum F09N35 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 905.0 nM
Antimicrobial activity against Plasmodium falciparum F09N58 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 448.0 nM
Antimicrobial activity against Plasmodium falciparum F09N66 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 711.0 nM
Antimicrobial activity against Plasmodium falciparum F09N68 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 288.0 nM
Antimicrobial activity against Plasmodium falciparum F07-6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 543.0 nM
Antimicrobial activity against Plasmodium falciparum F07-8 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 874.0 nM
Antimicrobial activity against Plasmodium falciparum F07-25 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 502.0 nM
Antimicrobial activity against Plasmodium falciparum F07-27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 650.0 nM
Antimicrobial activity against Plasmodium falciparum F07-28 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 473.0 nM
Antimicrobial activity against Plasmodium falciparum F07-29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 282.0 nM
Antimicrobial activity against Plasmodium falciparum F07-31 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 433.0 nM
Antimicrobial activity against Plasmodium falciparum F07-35 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 821.0 nM
Antimicrobial activity against Plasmodium falciparum F07-40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 298.0 nM
Antimicrobial activity against Plasmodium falciparum F07-42 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 388.0 nM
Antimicrobial activity against Plasmodium falciparum F07-58 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 680.0 nM
Antimicrobial activity against Plasmodium falciparum F08B9 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 218.0 nM
Antimicrobial activity against Plasmodium falciparum F08B27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 870.0 nM
Antimicrobial activity against Plasmodium falciparum F08B41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 886.0 nM
Antimicrobial activity against Plasmodium falciparum F08B63 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 579.0 nM
Antimicrobial activity against Plasmodium falciparum F08B72 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 583.0 nM
Antimicrobial activity against Plasmodium falciparum F09A10 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 716.0 nM
Antimicrobial activity against Plasmodium falciparum F09A61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 373.0 nM
Antimicrobial activity against Plasmodium falciparum F09N6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 710.0 nM
Antimicrobial activity against Plasmodium falciparum F09N22 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 535.0 nM
Antimicrobial activity against Plasmodium falciparum F09N29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 853.0 nM
Antimicrobial activity against Plasmodium falciparum F09N33 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 490.0 nM
Antimicrobial activity against Plasmodium falciparum F09N44 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 514.0 nM
Antimicrobial activity against Plasmodium falciparum F09N64 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 475.0 nM
Antimicrobial activity against Plasmodium falciparum F09N78 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 513.0 nM
Antimicrobial activity against Plasmodium falciparum Feng harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 371.0 nM
Antimicrobial activity against Plasmodium falciparum PF18 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 300.0 nM
Antimicrobial activity against Plasmodium falciparum F07-34 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 574.0 nM
Antimicrobial activity against Plasmodium falciparum F08B60 harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 767.0 nM
Antimicrobial activity against Plasmodium falciparum F09A21 harboring pfnhe1 ms4760 haplotype 18 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 258.0 nM
Antimicrobial activity against Plasmodium falciparum F07-47 harboring pfnhe1 ms4760 haplotype 20 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 324.0 nM
Antimicrobial activity against Plasmodium falciparum F08B40 harboring pfnhe1 ms4760 haplotype 21 carrying 1 copy of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 260.0 nM
Antimicrobial activity against Plasmodium falciparum SM harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 188.0 nM
Antimicrobial activity against Plasmodium falciparum FCC1/HN harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 179.0 nM
Antimicrobial activity against Plasmodium falciparum W2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 720.0 nM
Antimicrobial activity against Plasmodium falciparum 3D7 harboring pfnhe1 ms4760 haplotype 2 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 108.0 nM
Antimicrobial activity against Plasmodium falciparum 7G8 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034C 1042D 1246Y and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 619.0 nM
Antimicrobial activity against Plasmodium falciparum Dd2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 602.0 nM
Antimicrobial activity against Plasmodium falciparum K1 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 407.0 nM
Antimicrobial activity against Plasmodium falciparum HB3 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 319.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes 5,34 carrying4 copies of DNNND repeat and His/Asp ratio 5:8 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 462.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND repeat and His/Asp ratio 5:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 661.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND repeat and His/Asp ratio 6:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 767.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND repeat and His/Asp ratio 7:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 837.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND repeat and His/Asp ratio 5:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 580.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes1,18 carrying 2 copies of DNNND repeat and His/Asp ratio 7:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 312.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 35 carrying 1 copy of DNNND repeat and His/Asp ratio 5:2 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 260.0 nM
Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND repeat and His/Asp ratio 6:2 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay Plasmodium falciparum 223.0 nM
Antimicrobial activity against leupeptin resistant-Plasmodium falciparum HB3-leuR1 mutant infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay Plasmodium falciparum 73.96 nM
Antimicrobial activity against wild type Plasmodium falciparum HB3 infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay Plasmodium falciparum 77.13 nM
Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H] hypoxanthine incorporation after 24 hrs by scintillation counting Plasmodium falciparum 140.0 nM
Antimalarial activity against chloroquine sensitive Plasmodium falciparum HB3 after 72 hrs by SYBP Green I dye staining Plasmodium falciparum HB3 81.0 nM
Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining Plasmodium falciparum 320.0 nM
Antimalarial activity against trophozoite stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs Plasmodium falciparum 0.268 ug.mL-1
TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes Xenopus laevis 280.0 nM
TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells None 900.0 nM
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes Xenopus laevis 930.0 nM
Antiplasmodial against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting Plasmodium falciparum 0.7 nM
Antiplasmodial against chloroquine-rsistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting Plasmodium falciparum K1 20.4 nM
Antiplasmodial against chloroquine-rsistant Plasmodium falciparum W2 after 2 days by flow cytometry Plasmodium falciparum 18.7 nM
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate alamar blue assay Mycobacterium tuberculosis H37Rv 95.0 %
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 10 days by low oxygen recovery assay Mycobacterium tuberculosis H37Rv 98.0 %
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting Homo sapiens 54.0 %
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting Homo sapiens -1.3 %
Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting Homo sapiens -22.9 %
Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method Plasmodium falciparum K1 81.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method Plasmodium falciparum 3D7 34.0 nM
Antiamoebic activity against Entamoeba histolytica Entamoeba histolytica 14.8 ug.mL-1
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum MRC 20 infected in human red blood cells measured up to 24 hr Plasmodium falciparum 29.0 ug.mL-1
Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR-3 assessed as growth inhibition after 24 hrs by [3H]-hypoxanthine incorporation assay Plasmodium falciparum FCR-3/Gambia 170.0 nM
Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite LDH activity by three-fold serial dilution method Plasmodium falciparum 0.2 ug.mL-1
Antileishmanial activity against Leishmania mexicana mexicana MHOM/BZ/84/BEL46 promastigotes assessed as parasite LDH activity by three-fold serial dilution method Leishmania mexicana mexicana 20.0 ug.mL-1
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream form assessed as parasite LDH activity by three-fold serial dilution method Trypanosoma brucei brucei 6.87 ug.mL-1
Cytotoxicity against human WI38 cells by MTT assay Homo sapiens 6.56 ug.mL-1
Antimalarial activity against gametocytic stage of Plasmodium berghei infected in blood assessed as inhibition of ookinete formation at 10 uM after 24 hrs by Giemsa staining-based microscopic analysis relative to control Plasmodium berghei 50.0 %
Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry Plasmodium falciparum 18.67 nM
Antiviral activity against Chikungunya virus Chikungunya virus 0.1 ug.mL-1
Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis Plasmodium falciparum 3D7 178.0 nM
Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis Plasmodium falciparum 3D7 112.0 nM
Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis Plasmodium falciparum 917.0 nM
Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis Plasmodium falciparum 583.0 nM
Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis Plasmodium falciparum 608.0 nM
Antimalarial activity against chloroquine/quinine sensitive Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs Plasmodium falciparum 0.268 ug.mL-1
Antimalarial activity against chloroquine ane quinine-sensitive ring stage of Plasmodium falciparum assessed as inhibition of parasite growth after 48 hrs Plasmodium falciparum 0.268 ug.mL-1
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 Plasmodium falciparum K1 113.0 nM
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 80.0 nM
Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58 Plasmodium falciparum 199.0 nM
Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35 Plasmodium falciparum 431.0 nM
Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay Plasmodium falciparum 3D7 632.7 nM
Antiplasmodial activity against CQ-sensitive Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 18.0 nM
Antimalarial activity against Plasmodium falciparum after 48 hrs Plasmodium falciparum 826.0 nM
Antimalarial activity against blood stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by SYBR green I fluorescence-based method Plasmodium falciparum 3D7 58.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes measured after 48 hrs by Malstat/nitroblue tetrazolium/phenazine ethosulphate reagent based LDH assay Plasmodium falciparum NF54 180.0 nM
Antimalarial activity against Plasmodium falciparum Plasmodium falciparum 0.271 ug.mL-1
Antiviral activity against Chikungunya virus infected in African green monkey Vero cells Chikungunya virus 0.1 ug.mL-1
Antimalarial activity against Plasmodium falciparum in infected in human RBC Plasmodium falciparum 0.268 ug.mL-1
Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay Plasmodium falciparum 3D7 18.0 nM
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay Plasmodium falciparum 3D7 18.0 nM
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Homo sapiens 45.57 %
Inhibition of human CYP2D6 preincubated for 5 mins followed by NADPH addition and measured after 45 mins by luminescence based microplate reader analysis Homo sapiens 10.0 nM
Inhibition of human TASK3 expressed in Xenopus oocytes at 100 uM by whole cell patch clamp assay relative to control Homo sapiens 36.9 %
Inhibition of human TASK1 expressed in Xenopus oocytes at 100 uM by whole cell voltage clamp assay Homo sapiens 20.0 %
Antimalarial activity against Plasmodium falciparum FCR3 infected in human erythrocytes by Giemsa staining analysis Plasmodium falciparum 0.268 ug.mL-1 Antimalarial activity against Plasmodium falciparum FCR3 infected in human erythrocytes by Giemsa staining analysis Plasmodium falciparum 267.92 nM
Antiplasmodial activity against Plasmodium falciparum Plasmodium falciparum 0.268 ug.mL-1
Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay Plasmodium falciparum 254.0 nM
Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay Plasmodium falciparum 215.0 nM
Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay Plasmodium falciparum 199.0 nM
Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay Plasmodium falciparum 197.0 nM
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 16.93 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 6.66 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 24.14 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus 0.23 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.1 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.06 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus 0.23 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.06 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.1 %
Antimalarial activity against chloroquine and quinine sensitive Plasmodium falciparum Plasmodium falciparum 0.268 ug.mL-1
Antimalarial activity against Plasmodium falciparum 3D7A asexual forms assessed as inhibition of [G-3H]hypoxanthine uptake incubated for 24 hrs followed by [G-3H]hypoxanthine addition and measured after 18 hrs by liquid scintillation spectrometry Plasmodium falciparum 66.0 nM
Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition Plasmodium falciparum 0.268 ug.mL-1
Antimalarial activity against synchronized ring stage chloroquine-sensitive Plasmodium falciparum assessed as parasite growth inhibition incubated for 48 hrs in presence of 10% human plasma by hypoxanthine assay Plasmodium falciparum 826.0 nM
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs by lactate dehydrogenase assay Plasmodium falciparum 108.0 nM

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Cross References

Resources Reference
ChEBI 15854
ChEMBL CHEMBL170
DrugBank DB00468
DrugCentral 4523
FDA SRS A7V27PHC7A
Human Metabolome Database HMDB0014611
Guide to Pharmacology 2510
PDB QI9
PubChem 3034034
SureChEMBL SCHEMBL27031
ZINC ZINC000003831404
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