PICTILISIB


Synonyms	CDC-0941 GDC 0941 GDC-0941 Pictilisib Pictrelisib Rg-7321
Status
Molecule Category	Free-form
UNII	ICY00EMP8P
EPA CompTox	DTXSID40241930


InChI Key	LHNIIDJUOCFXAP-UHFFFAOYSA-N
Smiles	CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1
InChI	InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)

Mechanism of Action	Action	Reference
PI3-kinase class I inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase AKT family	-	28-46	-	-	-
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family Atypical protein kinase FRAP subfamily	-	3-959	48-200	570-580	-
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase RIO family Atypical protein kinase RIO2 subfamily	-	-	670	-	-
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase MLCK family	-	-	780	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CLK family	-	-	600	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase DYRK family CMGC protein kinase HIPK subfamily	-	-	520-600	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase JNK subfamily	-	-	560	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakA family	-	-	430	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakB family	-	-	430	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	-	710	-	59
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Trk family	-	-	-	-	61
Enzyme Transferase	-	3-900.9	0.76-300	1.4-31	-
Enzyme	-	3-900.9	0.76-300	1.4-31	59

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	170-720	3-959	0.76-48	1.4-580	59-61
Mus musculus	-	-	-	-	29-83


Protein: PI3-kinase class I Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Organism : Homo sapiens O00329 ENSG00000171608












Protein: PI3-kinase class I Description: Phosphatidylinositol 3-kinase regulatory subunit beta Organism : Homo sapiens O00459 ENSG00000105647











Protein: PI3-kinase class I Description: Phosphatidylinositol 3-kinase regulatory subunit alpha Organism : Homo sapiens P27986 ENSG00000145675












Protein: PI3-kinase class I Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Organism : Homo sapiens P42336 ENSG00000121879












Protein: PI3-kinase class I Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Organism : Homo sapiens P42338 ENSG00000051382












Protein: PI3-kinase class I Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Organism : Homo sapiens P48736 ENSG00000105851












Protein: PI3-kinase class I Description: Phosphoinositide 3-kinase regulatory subunit 5 Organism : Homo sapiens Q8WYR1 ENSG00000141506











Protein: PI3-kinase class I Description: Phosphatidylinositol 3-kinase regulatory subunit gamma Organism : Homo sapiens Q92569 ENSG00000117461

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