PF-03463275

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Synonyms
Status
Molecule Category Free-form
UNII 3U6T9EE6UX

Structure

InChI Key KYLOBHXXQOZRKK-FICVDOATSA-N
Smiles CN1C[C@@H]2[C@H](C1)[C@H]2CN(Cc1ccc(F)c(Cl)c1)C(=O)c1cn(C)cn1
InChI
InChI=1S/C19H22ClFN4O/c1-23-7-13-14(8-23)15(13)9-25(19(26)18-10-24(2)11-22-18)6-12-3-4-17(21)16(20)5-12/h3-5,10-11,13-15H,6-9H2,1-2H3/t13-,14+,15+

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H22ClFN4O
Molecular Weight 376.86
AlogP 2.66
Hydrogen Bond Acceptor 4.0
Number of Rotational Bond 5.0
Polar Surface Area 41.37
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 26.0

Pharmacology

Mechanism of Action Action Reference
Glycine transporter 1 inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- - - 11.6 -

Target Conservation

Protein: Glycine transporter 1
Description: Sodium- and chloride-dependent glycine transporter 1
Organism : Homo sapiens
P48067 ENSG00000196517

Cross References

Resources Reference
ChEMBL CHEMBL563251
DrugBank DB11993
FDA SRS 3U6T9EE6UX
Guide to Pharmacology 9057
ZINC ZINC000101270900
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