|
Inhibitory activity against influenza A neuraminidase
|
Influenza A virus
|
1.0
nM
|
|
|
Inhibitory activity against influenza B neuraminidase
|
Influenza B virus
|
5.0
nM
|
|
|
Inhibition of influenza A virus (A/duck/Minnesota/1525/1981 (H5N1)) replication in MDCK cells by neutral red uptake assay
|
Influenza A virus (A/duck/Minnesota/1525/1981(H5N1))
|
140.0
nM
|
|
|
Inhibition of Influenza A virus (A/gull/Pennsylvania/4175/83 (H5N1)) replication in MDCK cells by neutral red uptake assay
|
Influenza A virus (A/gull/Pennsylvania/4175/83(H5N1))
|
280.0
nM
|
|
|
Inhibition of viral replication of influenza A virus (A/Hong Kong/213/03(H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by neutral red uptake assay
|
Influenza A virus
|
32.0
nM
|
|
|
Inhibition of viral replication of influenza A virus (A/Vietnam/1203/2004 (H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by neutral red uptake assay
|
Influenza A virus
|
1.4
nM
|
|
|
Inhibition of influenza B/Memphis/3/89 neuraminidase
|
Influenza B virus (B/Memphis/3/89)
|
1.1
nM
|
|
|
Inhibition of influenza A/N1/PR/8/34 neuraminidase
|
Influenza A virus
|
0.1
nM
|
|
|
Antiviral activity against influenza H3N2 virus
|
H3N2 subtype
|
260.0
nM
|
|
|
Inhibition of Influenza Virus A/Potsdam/15/81 (H1N1) neuraminidase
|
Influenza A virus
|
0.16
nM
|
|
|
Inhibition of Influenza Virus A/Belzig/2/01 (H1N1) neuraminidase
|
Influenza A virus (A/swine/Belzig/2/2001(H1N1))
|
0.2
nM
|
|
|
Inhibition of Influenza Virus A/Horneburg/IDT7489/08 (H1N1) neuraminidase
|
Influenza A virus
|
0.06
nM
|
|
|
Inhibition of Influenza Virus A/Brest/IDT7490/08 (H1N1) neuraminidase
|
Influenza A virus
|
0.19
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) in MDCK cells assessed as reduction in plaque number by plaque reduction assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
194.1
nM
|
|
|
Antiviral activity against Influenza A virus (A/Hong Kong/7/87(H3N2)) assessed as inhibition of virus-induced cytopathic effect by cell-based assay
|
Influenza A virus (A/Hong Kong/7/1987(H3N2))
|
800.0
nM
|
|
|
Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase
|
Influenza A virus
|
1.59
nM
|
|
|
Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
0.000681
ug.mL-1
|
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) recombinant wild type neuraminidase expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
9.9
nM
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) recombinant wild type neuraminidase expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
144.2
nM
|
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) recombinant neuraminidase E197 mutant expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
84.0
nM
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) recombinant neuraminidase E197 mutant expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
659.7
nM
|
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) wild type recombinant neuraminidase expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
16.6
nM
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) wild type recombinant neuraminidase expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
104.4
nM
|
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) recombinant neuraminidase E197 mutant expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
82.0
nM
|
|
Inhibition of Influenza B virus (B/Perth/211/2001) recombinant neuraminidase E197 mutant expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus (B/Perth/211/2001)
|
708.0
nM
|
|
|
Inhibition of Influenza B virus B/Gifu/11/2005 wild type neuraminidase expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus
|
6.0
nM
|
|
Inhibition of Influenza B virus B/Gifu/11/2005 wild type neuraminidase expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus
|
65.0
nM
|
|
|
Inhibition of Influenza B virus B/Yamagata/186/05 neuraminidase N197 mutant expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus
|
53.4
nM
|
|
Inhibition of Influenza B virus B/Yamagata/186/05 neuraminidase N197 mutant expressed in Sf21 insect cells after 60 mins by MUNANA based assay
|
Influenza B virus
|
182.5
nM
|
|
|
Inhibition of Influenza B virus B/Gifu/11/2005 wild type neuraminidase expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus
|
6.7
nM
|
|
Inhibition of Influenza B virus B/Gifu/11/2005 wild type neuraminidase expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus
|
45.0
nM
|
|
|
Inhibition of Influenza B virus B/Yamagata/186/05 neuraminidase N197 mutant expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus
|
60.7
nM
|
|
Inhibition of Influenza B virus B/Yamagata/186/05 neuraminidase N197 mutant expressed in Sf21 insect cells preincubated for 30 mins measured after 60 mins by MUNANA based assay
|
Influenza B virus
|
188.4
nM
|
|
|
Antiviral activity against sInfluenza A virus (A/Texas/12/2007 (H3N2)) with neuraminidase E119V mutant isolated from immunocompromized patient measured after X/CD2 additional passages in MDCK cells by NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
9.18
nM
|
|
|
Antiviral activity against Influenza A virus (A/Texas/12/2007 (H3N2)) with neuraminidase E119(V/I) mutant isolated from immunocompromized patient measured after X/CD3 additional passages in MDCK cells by NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
8.06
nM
|
|
|
Antiviral activity against Influenza A virus (A/Texas/12/2007 (H3N2)) clone 1 with neuraminidase E119V mutant isolated from immunocompromized patient measured after X/CD4 additional passages in MDCK cells by NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
5.49
nM
|
|
|
Antiviral activity against Influenza A virus (A/Texas/12/2007 (H3N2)) clone 2 with neuraminidase E119I mutant isolated from immunocompromized patient measured after X/CD4 additional passages in MDCK cells by NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
33.25
nM
|
|
|
Antiviral activity against Influenza A virus (A/Washington/01/2007 (H3N2)) measured in MDCK cells by NA inhibition assay
|
Influenza A virus (A/Washington/01/2007(H3N2))
|
0.16
nM
|
|
|
Antiviral activity against sInfluenza A virus (A/Texas/12/2007 (H3N2)) with neuraminidase E119(V/I) mutant isolated from immunocompromized patient measured after X/CD3 additional passages in MDCK cells by fluorescent NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
154.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Texas/12/2007 (H3N2)) clone 1 with neuraminidase E119V mutant isolated from immunocompromized patient measured after X/CD4 additional passages in MDCK cells by fluorescent NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
245.5
nM
|
|
|
Antiviral activity against Influenza A virus (A/Texas/12/2007 (H3N2)) clone 2 with neuraminidase E119I mutant isolated from immunocompromized patient measured after X/CD4 additional passages in MDCK cells by fluorescent NA inhibition assay
|
Influenza A virus (A/Texas/12/2007(H3N2))
|
430.59
nM
|
|
|
Antiviral activity against Influenza A virus (A/Washington/01/2007 (H3N2)) measured in MDCK cells by fluorescent NA inhibition assay
|
Influenza A virus (A/Washington/01/2007(H3N2))
|
0.44
nM
|
|
|
Inhibition of influenza A virus H1N1 Neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid sodium salt hydrate substrate
|
Influenza A virus
|
0.03974
ug.mL-1
|
|
|
Inhibition of influenza A virus H9N2 Neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid sodium salt hydrate substrate
|
Influenza A virus
|
0.00494
ug.mL-1
|
|
|
Inhibition of human Influenza A virus A/PR/8/34(H1N1) neuraminidase by fluorometric method using 4MU-NeuAc substrate
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
7.09
nM
|
|
|
Inhibition of human influenza A virus A/Aichi/2/1968(H3N2) neuraminidase by fluorometric method using 4MU-NeuAc substrate
|
Influenza A virus (A/Aichi/2/1968(H3N2))
|
1.55
nM
|
|
|
Inhibition of human influenza A virus A/DK/HK/313/4/78(H5N3) neuraminidase by fluorometric method using 4MU-NeuAc substrate
|
Influenza A virus
|
4.95
nM
|
|
|
Antiviral activity against influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathogenicity after 2 days
|
Influenza A virus
|
0.2
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathogenicity after 2 days
|
Influenza A virus H3N2
|
4.0
ug.mL-1
|
|
|
Antiviral activity against influenza B virus infected in MDCK cells assessed as protection against virus-induced cytopathogenicity after 2 days
|
Influenza B virus
|
2.0
ug.mL-1
|
|
|
Antiviral activity against influenza A virus H1N1 infected in MDCK cells assessed as cell viability after 2 days by MTS assay
|
Influenza A virus
|
0.1
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as cell viability after 2 days by MTS assay
|
Influenza A virus H3N2
|
3.8
ug.mL-1
|
|
|
Antiviral activity against influenza B virus infected in MDCK cells assessed as cell viability after 2 days by MTS assay
|
Influenza B virus
|
1.5
ug.mL-1
|
|
|
Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
2.39
nM
|
|
|
Inhibition of Influenza A virus (A/Yamagata/32/1989(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus (A/Yamagata/32/1989(H1N1))
|
1.54
nM
|
|
|
Inhibition of Influenza A virus (A/New Caledonia/20/1999(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus (A/New Caledonia/20/1999(H1N1))
|
1.58
nM
|
|
|
Inhibition of Influenza A virus (A/Shiga/1/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.34
nM
|
|
|
Inhibition of Influenza A virus (A/Yamagata/3/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.08
nM
|
|
|
Inhibition of Influenza A virus (A/Yamagata/57/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.658
nM
|
|
|
Inhibition of Influenza A virus (A/Saitama/78/2003(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.12
nM
|
|
|
Inhibition of Influenza A virus (A/Aichi/193/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.26
nM
|
|
|
Inhibition of Influenza A virus (A/Okinawa/42/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.86
nM
|
|
|
Inhibition of Influenza A virus (A/Aichi/169/2005(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.12
nM
|
|
|
Inhibition of Influenza A virus (A/Yamagata/83/2006(H1N1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.785
nM
|
|
|
Inhibition of Influenza A virus (A/Singapore/1/1957(H2N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.925
nM
|
|
|
Inhibition of Influenza A virus (A/Aichi/2/1968(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.39
nM
|
|
|
Inhibition of Influenza A virus (A/Kitakyushu/159/1993(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.6
nM
|
|
|
Inhibition of Influenza A virus (A/Wyoming/03/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.71
nM
|
|
|
Inhibition of Influenza A virus (A/Wellington/1/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.99
nM
|
|
|
Inhibition of Influenza A virus (A/California/07/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.9
nM
|
|
|
Inhibition of Influenza A virus (A/New York/55/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.56
nM
|
|
|
Inhibition of Influenza A virus (A/Hiroshima/52/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.33
nM
|
|
|
Inhibition of Influenza A virus (A/Wisconsin/67/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus (A/Wisconsin/67/2005(H3N2))
|
3.44
nM
|
|
|
Inhibition of Influenza A virus (A/Shiga/5/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.706
nM
|
|
|
Inhibition of Influenza A virus (A/Yamagata/1/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.09
nM
|
|
|
Inhibition of Influenza A virus (A/Yamagata/2/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.981
nM
|
|
|
Inhibition of Influenza A virus (A/Saitama/80/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.711
nM
|
|
|
Inhibition of Influenza A virus (A/Osaka/56/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.08
nM
|
|
|
Inhibition of Influenza A virus (A/Tokushima/1/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.925
nM
|
|
|
Inhibition of Influenza A virus (A/Saitama/07/2006(H3N2)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
0.885
nM
|
|
|
Inhibition of Influenza B virus (B/Brisbane/32/2002(Victoria) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
13.6
nM
|
|
|
Inhibition of Influenza B virus (B/Malaysia/2506/2004(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
15.1
nM
|
|
|
Inhibition of Influenza B virus (B/Ohio/01/2005(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
13.6
nM
|
|
|
Inhibition of Influenza B virus (B/Shiga/17/2002(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
8.72
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/15/2002(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
7.25
nM
|
|
|
Inhibition of Influenza B virus (B/Akita/9/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
9.55
nM
|
|
|
Inhibition of Influenza B virus (B/Tokushima/1/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
9.26
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/145/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
3.09
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/398/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
10.1
nM
|
|
|
Inhibition of Influenza B virus (B/Aichi/3/2006(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
12.4
nM
|
|
|
Inhibition of Influenza B virus (B/Saitama/01/2006(Victoria)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
13.7
nM
|
|
|
Inhibition of Influenza B virus (B/Mie/1/1993(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
15.6
nM
|
|
|
Inhibition of Influenza B virus (B/Shanghai/361/2002(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
12.0
nM
|
|
|
Inhibition of Influenza B virus (B/Shiga/31/2002(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
9.16
nM
|
|
|
Inhibition of Influenza B virus (B/Shizuoka/58/2004(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
8.34
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/85/2004(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
8.84
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/87/2004(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
8.26
nM
|
|
|
Inhibition of Influenza B virus (B/Aichi/186/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
9.21
nM
|
|
|
Inhibition of Influenza B virus (B/Saitama/01/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
10.6
nM
|
|
|
Inhibition of Influenza B virus (B/Sapporo/29/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
9.62
nM
|
|
|
Inhibition of Influenza B virus (B/Tokushima/1/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
8.35
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/1/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
9.44
nM
|
|
|
Inhibition of Influenza B virus (B/Yamagata/113/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza B virus
|
10.6
nM
|
|
|
Inhibition of Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01)(H5H1)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.17
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Hokkaido/84/2002(H5N3)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.94
nM
|
|
|
Inhibition of Influenza A virus (A/turkey/Ontario/6,118/1968(H8N4)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
3.65
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Alberta/60/1976(H12N5)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.43
nM
|
|
|
Inhibition of Influenza A virus (A/duck/England/1/1956(H11N6)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.81
nM
|
|
|
Inhibition of Influenza A virus (A/seal/Massachusetts/1/1980(H7N7)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.56
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.12
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Memphis/546/1974(H11N9)) neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.7
nM
|
|
|
Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 1)(H1N1)) wild type neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
2.28
nM
|
|
|
Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 11)(H1N1)) neuraminidase H274Y mutant after 30 mins by fluorescence analysis
|
Influenza A virus
|
755.0
nM
|
|
|
Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.25
nM
|
|
|
Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.78
nM
|
|
|
Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) neuraminidase E119V mutant after 30 mins by fluorescence analysis
|
Influenza A virus
|
140.0
nM
|
|
|
Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis
|
Influenza A virus
|
1.18
nM
|
|
|
Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) neuraminidase N294S mutant after 30 mins by fluorescence analysis
|
Influenza A virus
|
37.2
nM
|
|
|
Inhibition of Influenza B virus (B/Yokohama/UT2203/2005)) neuraminidase N294S mutant after 30 mins by fluorescence analysis
|
Influenza B virus
|
40.5
nM
|
|
|
Inhibition of Influenza B virus (B/Yokohama/UT3318/2005)) neuraminidase N294S mutant after 30 mins by fluorescence analysis
|
Influenza B virus
|
68.8
nM
|
|
|
Antiviral activity against Influenza A H1N1 virus subtype infected in MDCK cells assessed as inhibition of virus induced cytopathicity by visual scoring of CPE
|
Influenza A virus
|
12.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A H1N1 virus subtype infected in MDCK cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay
|
Influenza A virus
|
28.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A H3N2 virus subtype infected in MDCK cells assessed as inhibition of virus induced cytopathicity by visual scoring of CPE
|
Influenza A virus H3N2
|
9.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A H3N2 virus subtype infected in MDCK cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay
|
Influenza A virus H3N2
|
6.9
ug.mL-1
|
|
|
Antiviral activity against Influenza B virus infected in MDCK cells assessed as inhibition of virus induced cytopathicity by visual scoring of CPE
|
Influenza B virus
|
100.0
ug.mL-1
|
|
|
Antiviral activity against Influenza B virus infected in MDCK cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay
|
Influenza B virus
|
100.0
ug.mL-1
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase activity after 2 hrs by spectrofluorometry
|
Influenza A virus
|
0.03974
ug.mL-1
|
|
|
Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
|
H1N1 swine influenza virus
|
0.02109
ug.mL-1
|
|
|
Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
|
H1N1 swine influenza virus
|
5.13
ug.mL-1
|
|
|
Inhibition of Influenza A H9N2 virus neuraminidase activity after 2 hrs by spectrofluorometry
|
Influenza A virus
|
0.00494
ug.mL-1
|
|
|
Antiviral activity against influenza virus (A/Sidney/5/97 (H3N2)) R292 infected in MDCK cells expressing human ST6Gal 1 gene after 48 to 72 hrs by plaque assay
|
Influenza A virus
|
0.01023
ug.mL-1
|
|
|
Antiviral activity against influenza virus (A/Sidney/5/97 (H3N2)) R292 infected in MDCK cells expressing human ST6Gal 1 gene in hollow fiber model system assessed as decrease in viral replication after 48 to 72 hrs by plaque assay
|
Influenza A virus
|
0.000726
ug.mL-1
|
|
|
Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by fluorometric assay
|
Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))
|
0.3
nM
|
|
|
Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by fluorometric assay
|
Influenza A virus (A/Turkey/651242/2006(H5N1))
|
10.8
nM
|
|
|
Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by fluorometric assay
|
Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1))
|
4.9
nM
|
|
|
Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by fluorometric assay
|
Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1))
|
1.5
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by fluorometric assay
|
Influenza A virus (A/duck/Laos/25/2006(H5N1))
|
0.1
nM
|
|
|
Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by by Michaelis-Menten equation analysis
|
Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))
|
0.1
nM
|
|
|
Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis
|
Influenza A virus (A/Turkey/651242/2006(H5N1))
|
7.9
nM
|
|
|
Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by Michaelis-Menten equation analysis
|
Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1))
|
4.9
nM
|
|
|
Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by Michaelis-Menten equation analysis
|
Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1))
|
0.9
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis
|
Influenza A virus (A/duck/Laos/25/2006(H5N1))
|
1.1
nM
|
|
|
Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay
|
Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))
|
0.2
nM
|
|
|
Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase A119A mutant isolated from virus-infected BALB/c mouse by fluorometric assay
|
Influenza A virus (A/Turkey/651242/2006(H5N1))
|
136.9
nM
|
|
|
Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay
|
Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1))
|
3.7
nM
|
|
|
Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay
|
Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1))
|
1.2
nM
|
|
|
Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay
|
Influenza A virus (A/duck/Laos/25/2006(H5N1))
|
0.1
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 1 nM of oseltamivir after 1 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 5 nM of oseltamivir after 2 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 25 nM of oseltamivir after 3 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 50 nM of oseltamivir after 4 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 250 nM of oseltamivir after 5 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring neuraminidase H274Y mutant infected in MDCK cells selected at 1250 nM of oseltamivir after 6 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
25.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring neuraminidase H274Y mutant infected in MDCK cells selected at 6250 nM of oseltamivir after 7 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
145.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 1 nM of oseltamivir after 1 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 5 nM of oseltamivir after 2 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 25 nM of oseltamivir after 3 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 125 nM of oseltamivir after 4 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 625 nM of oseltamivir after 5 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.4
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase I222M mutant infected in MDCK cells selected at 3,125 nM of oseltamivir after 6 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.4
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 1 nM of zanamivir after 1 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 5 nM of zanamivir after 2 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 25 nM of zanamivir after 3 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 50 nM of zanamivir after 4 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells selected at 250 nM of zanamivir after 5 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring hemagglutininin K234N mutant gene and neuraminidase D198G mutant infected in MDCK cells selected at 1250 nM of compound after 6 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring hemagglutininin K234N mutant gene and neuraminidase D198G mutant infected in MDCK cells selected at 6250 nM of compound after 7 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.4
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 1 nM of compound after 1 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 5 nM of zanamivir after 2 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 25 nM of zanamivir after 3 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 125 nM of zanamivir after 4 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 625 nM of zanamivir after 5 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells selected at 3,125 nM of zanamivir after 6 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase E119G mutant infected in MDCK cells selected at 16 uM of zanamivir after 7 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
300.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase E119G mutant infected in MDCK cells selected at 78 uM of zanamivir after 8 passage after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
900.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase I222V mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
5.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
695.6
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase I222M mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
27.8
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) infected in MDCK cells after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) infected in MDCK cells after 48 hrs by hemagglutininin titer assay
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring neuraminidase E119G mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
3.1
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring wild type neuraminidase
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
498.9
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring neuraminidase D198G mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring wild type neuraminidase
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
6.4
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring neuraminidase E119G mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring wild type neuraminidase
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.7
nM
|
|
|
Antiviral activity against Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring neuraminidase I222M mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring wild type neuraminidase
|
Influenza A virus (A/New Caledonia/20/1999(H1N1))
|
11.9
nM
|
|
|
Antiviral activity against Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring neuraminidase I222V mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring wild type neuraminidase
|
Influenza A virus (A/New Caledonia/20/1999(H1N1))
|
4.5
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Laos/26/2006(H5N1)) harboring wild type neuraminidase infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose
|
Influenza A virus (A/Chicken/Laos/Xaythiani 26/2006(H5N1))
|
0.8
nM
|
|
|
Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring wild type neuraminidase infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring wild type neuraminidase
|
Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1))
|
0.2
nM
|
|
|
Antiviral activity against Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring wild type neuraminidase infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring wild type neuraminidase
|
Influenza A virus (A/New Caledonia/20/1999(H1N1))
|
1.5
nM
|
|
|
Antiviral activity against influenza A (A/Washington/10/2008 (H1N1)) virus after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
0.25
nM
|
|
|
Antiviral activity against influenza A (A/North Carolina/02/2009 (H1N1)) virus after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
0.25
nM
|
|
|
Antiviral activity against influenza A (A/New York/18/2009 (H1N1)) virus after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
0.54
nM
|
|
|
Antiviral activity against influenza A (A/Washington/29/2009 (H1N1)) virus after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
0.34
nM
|
|
|
Antiviral activity against influenza A (A/Singapore/91/2009 (H1N1)) virus after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
0.49
nM
|
|
|
Antiviral activity against influenza A (A/North Carolina/01/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
94.4
nM
|
|
|
Antiviral activity against influenza A (A/Montana/02/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
99.57
nM
|
|
|
Antiviral activity against influenza A (A/Osaka/180/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
93.92
nM
|
|
|
Antiviral activity against influenza A (A/Washington/29/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
95.43
nM
|
|
|
Antiviral activity against influenza A (A/Hong Kong/2369/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
78.12
nM
|
|
|
Antiviral activity against influenza A (A/Singapore/57/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
|
Influenza A virus
|
75.29
nM
|
|
|
Antiviral activity against influenza A (A/Washington/10/2008 (H1N1)) virus after 30 mins by MUNANA substrate based fluorometric assay
|
Influenza A virus
|
0.85
nM
|
|
|
Antiviral activity against influenza A (A/North Carolina/02/2009 (H1N1)) virus after 30 mins by MUNANA substrate based fluorometric assay
|
Influenza A virus
|
1.08
nM
|
|
|
Antiviral activity against influenza A (A/New York/18/2009 (H1N1)) virus after 30 mins by MUNANA substrate based fluorometric assay
|
Influenza A virus
|
1.84
nM
|
|
|
Antiviral activity against influenza A (A/Washington/29/2009 (H1N1)) virus after 30 mins by MUNANA substrate based fluorometric assay
|
Influenza A virus
|
1.59
nM
|
|
|
Antiviral activity against influenza A (A/Singapore/91/2009 (H1N1)) virus after 30 mins by MUNANA substrate based fluorometric assay
|
Influenza A virus
|
2.27
nM
|
|
|
Antiviral activity against influenza A (A/Hong Kong/2369/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by MUNANA substrate based fluorometric assay
|
Influenza A virus
|
976.71
nM
|
|
|
Antiviral activity against influenza A (A/Washington/10/2008 (H1N1)) virus after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
2.4
nM
|
|
|
Antiviral activity against influenza A (A/North Carolina/02/2009 (H1N1)) virus after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
7.03
nM
|
|
|
Antiviral activity against influenza A (A/New York/18/2009 (H1N1)) virus after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
3.79
nM
|
|
|
Antiviral activity against influenza A (A/Washington/29/2009 (H1N1)) virus after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
3.41
nM
|
|
|
Antiviral activity against influenza A (A/Singapore/91/2009 (H1N1)) virus after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
3.64
nM
|
|
|
Antiviral activity against influenza A (A/North Carolina/01/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
966.27
nM
|
|
|
Antiviral activity against influenza A (A/Montana/02/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
770.66
nM
|
|
|
Antiviral activity against influenza A (A/Washington/29/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
816.52
nM
|
|
|
Antiviral activity against influenza A (A/Singapore/57/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 16 to 18 hrs by fetuin substrate based colorimetric assay
|
Influenza A virus
|
945.39
nM
|
|
|
Inhibition of influenza A virus neuraminidase assessed as cleavage of MUNANA substrate by fluorescence assay
|
Influenza A virus
|
20.0
nM
|
|
|
Inhibition of influenza A virus neuraminidase
|
Influenza A virus
|
1.0
nM
|
|
|
Inhibition of viral neuraminidase after 20 mins by fluorescence assay
|
None
|
140.0
nM
|
|
|
Inhibition of Influenza A virus H7N1 N1 neuraminidase expressed in baculovirus using 2'-(4-Methylumbelliferyl)-alpha-D-acetyl neuraminic acid as substrate incubated for 2 hrs prior to substrate addition measured after 5 hrs by fluorimetry
|
Influenza A virus
|
24.9
nM
|
|
|
Inhibition of Influenza A virus H7N3 N3 neuraminidase expressed in baculovirus using 2'-(4-Methylumbelliferyl)-alpha-D-acetyl neuraminic acid as substrate incubated for 2 hrs prior to substrate addition measured after 5 hrs by fluorimetry
|
Influenza A virus
|
0.2
nM
|
|
|
Inhibition of Influenza A virus H1N1 neuraminidase using 4-MU-NANA as substrate by fluorescence assay
|
Influenza A virus
|
0.03974
ug.mL-1
|
|
|
Inhibition of Influenza A virus H9N2 neuraminidase using 4-MU-NANA as substrate by fluorescence assay
|
Influenza A virus
|
0.00494
ug.mL-1
|
|
|
Inhibition of wild type H1N1 swine influenza virus neuraminidase using 4-MU-NANA as substrate by fluorescence assay
|
H1N1 swine influenza virus
|
0.02109
ug.mL-1
|
|
|
Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant using 4-MU-NANA as substrate by fluorescence assay
|
H1N1 swine influenza virus
|
5.13
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/X-31(H3N2)) infected in MDCK cells assessed as virus-induced cytopathic effect measured 3 days post infection by microscopic analysis
|
Influenza A virus (A/X-31(H3N2))
|
110.0
nM
|
|
|
Antiviral activity against Influenza B virus (B/Lee/40) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis
|
Influenza B virus (B/Lee/40)
|
820.0
nM
|
|
|
Antiviral activity against Influenza B virus (B/Taiwan/2/62) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis
|
Influenza B virus
|
50.0
nM
|
|
|
Antiviral activity against Influenza B virus (B/Panama/45/1990) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis
|
Influenza B virus (B/Panama/45/1990)
|
60.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Hong kong/8/1968(H2N3)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis
|
Influenza A virus
|
10.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Taiwan/1/1986(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis
|
Influenza A virus (A/Taiwan/1/1986(H1N1))
|
50.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/chicken/Sandong/Li/2008(H9N2)) infected in chicken embryo fibroblast assessed as protection against virus-induced cytopathic effect after 2 days by MTS assay
|
Influenza A virus (A/chicken/Sandong/Li/2008(H9N2))
|
500.0
nM
|
|
|
Inhibition of Influenza A virus H1N1 A/duck/China/QJ/01 neuraminidase N1 using 4-MU-NANA as substrate after 5 mins by fluorescence assay
|
Influenza A virus
|
10.0
nM
|
|
|
Inhibition of Influenza A virus (A/chicken/Sandong/Li/2008(H9N2)) neuraminidase N2 using 4-MU-NANA as substrate after 5 mins by fluorescence assay
|
Influenza A virus (A/chicken/Sandong/Li/2008(H9N2))
|
1.7
nM
|
|
|
Antiviral activity against Influenza A virus (A/duck/Minnesota/1525/1981(H5N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect by cell-based neutral red uptake assay
|
Influenza A virus (A/duck/Minnesota/1525/1981(H5N1))
|
110.0
nM
|
|
|
Antiviral activity against influenza A virus H3N3 subtype infected in dog MDCK cells assessed as reduction of virus-induced cytopathogenicity by MTS assay
|
Influenza A virus
|
20.0
nM
|
|
|
Antiviral activity against influenza A virus H1N1 subtype infected in dog MDCK cells assessed as reduction of virus-induced cytopathogenicity by MTS assay
|
Influenza A virus
|
90.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Chicken/Shandong/LY/08(H9N2)) infected in chicken embryo fibroblasts assessed as protection against virus-induced cytopathic effect preincubated for 1 hr followed by viral-infection measured after 2 days by MTS assay
|
Influenza A virus (A/chicken/Shandong/LY/2008(H9N2))
|
240.0
nM
|
|
|
Inhibition of influenza A virus A/duck/China/QJ/01(H5N1) neuraminidase using 4-MU-NANA as substrate incubated for 5 mins prior to substrate addition measured after 30 to 60 mins by fluorescence assay
|
Influenza A virus
|
16.0
nM
|
|
|
Inhibition of Influenza A virus (A/Chicken/Shandong/LY/08(H9N2)) neuraminidase using 4-MU-NANA as substrate incubated for 5 mins prior to substrate addition measured after 30 to 60 mins by fluorescence assay
|
Influenza A virus (A/chicken/Shandong/LY/2008(H9N2))
|
2.8
nM
|
|
|
Inhibition of Influenza A virus A/California/07/2009 (H1N1) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs
|
Influenza A virus (A/California/07/2009(H1N1))
|
10.0
nM
|
|
|
Inhibition of Influenza A virus A/Hong Kong/8/1968 (H3N2) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs
|
Influenza A virus
|
8.0
nM
|
|
|
Antiviral activity against Influenza A virus A/California/07/2009 (H1N1) infected in MDCK cells assessed as reduction in virus plaque formation after 5 days
|
Influenza A virus (A/California/07/2009(H1N1))
|
1.0
nM
|
|
|
Antiviral activity against Influenza A virus A/Hong Kong/8/1968 (H3N2) infected in MDCK cells assessed as reduction in virus plaque formation after 5 days
|
Influenza A virus
|
1.0
nM
|
|
|
Inhibition of Influenza A virus H3N2 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs
|
Influenza A virus
|
50.0
nM
|
|
|
Inhibition of Influenza A virus H5N1 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs
|
Influenza A virus
|
50.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Hong Kong/1/1968(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
|
Influenza A virus (A/Hong Kong/1/1968(H3N2))
|
4.0
nM
|
|
|
Antiviral activity against Influenza A virus J/8178/09 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
|
Influenza A virus
|
30.0
nM
|
|
|
Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemiluminescence based assay
|
Influenza A virus (A/Hong Kong/1/1968(H3N2))
|
0.2
nM
|
|
|
Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay
|
Influenza A virus
|
80.0
nM
|
|
|
Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
0.3
nM
|
|
|
Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based assay
|
Influenza A virus
|
0.5
nM
|
|
|
Antiviral activity against Influenza A virus A/hanfang/359/95(H3N2) infected in MDCK cells assessed as inhibition of virus-induced cytopathicity after 40 hrs
|
Influenza A virus
|
1.0
ug.mL-1
|
|
|
Antiviral activity against oseltamivir-resistant Influenza A virus (A/Tianjinjinnan/15/2009/H1N1) infected in MDCK cells assessed as inhibition of virus-induced cytopathicity after 40 hrs
|
Influenza A virus (A/Tianjin-Jinnan/15/2009(H1N1))
|
500.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/FM/1/1947(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathicity after 40 hrs
|
Influenza A virus (A/Fort Monmouth/1/1947(H1N1))
|
2.81
ug.mL-1
|
|
|
Antiviral activity against Influenza B virus (B/Harbin/07/94) infected in MDCK cells assessed as reduction of virus-induced cytopathic effect after 72 hrs by MTT assay
|
Influenza B virus (B/Harbin/07/94)
|
583.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Sydney/5/1997(H3N2)) infected in MDCK cells assessed as reduction of virus-induced cytopathic effect after 72 hrs by MTT assay
|
Influenza A virus (A/Sydney/5/1997(H3N2))
|
98.0
nM
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate
|
influenza A virus
|
0.87
nM
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase at 100 nM after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate
|
influenza A virus
|
99.0
%
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase at 20 nM after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate
|
influenza A virus
|
97.0
%
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase at 4 nM after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate
|
influenza A virus
|
84.0
%
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase at 0.8 nM after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate
|
influenza A virus
|
51.0
%
|
|
|
Inhibition of Influenza A H1N1 virus neuraminidase at 0.16 nM after 1 hr by spectrofluorimetry using 2-(4-meythylumbelliferyl)-alpha-D-acetylneuramic acid as substrate
|
influenza A virus
|
17.0
%
|
|
|
Inhibition of influenza A virus (A/California/07/2009(H1N1)) pdm09 neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay
|
Influenza A virus (A/California/07/2009(H1N1))
|
2.57
nM
|
|
|
Inhibition of influenza A virus (A/Perth/16/2009(H3N2)) neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay
|
Influenza A virus (A/Perth/16/2009(H3N2))
|
1.39
nM
|
|
|
Inhibition of influenza B virus (B/Brisbane/60/2008) neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay
|
Influenza B virus (B/Brisbane/60/2008)
|
45.39
nM
|
|
|
Antiviral activity against Influenza A virus A/New York/18/2009 infected in MDCK cells assessed as cell protection after 3 days by cytopathic effect assay
|
Influenza A virus (A/New York/18/2009(H1N1))
|
160.0
nM
|
|
|
Antiviral activity against Influenza A virus A/Puerto Rico/8/34 infected in BALB/c mouse assessed as body weight loss at 30 mg/kg bid treated after 48 hrs of infection for 10 days
|
Influenza A virus (A/Puerto Rico/8/34(H1N1))
|
30.0
%
|
|
|
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining
|
influenza A virus
|
25.0
nM
|
|
|
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining
|
influenza A virus
|
15.0
nM
|
|
|
Inhibition of oseltamivir-resistant Influenza A virus H3N2 neuraminidase at 50 uM
|
influenza A virus
|
100.0
%
|
|
|
Inhibition of oseltamivir-resistant Influenza A virus H3N2 neuraminidase
|
influenza A virus
|
150.0
nM
|
|
|
Inhibition of Influenza A virus H1N1 wild type neuraminidase
|
influenza A virus
|
210.0
nM
|
|
|
Antiviral activity against Influenza A virus infected in MDCK cells after 72 hrs by yield reduction assay
|
influenza A virus
|
30.0
nM
|
|
|
Antiviral activity against oseltamivir-resistant influenza A virus LN/1109 (H1N1) infected in dog MDCK cells assessed as inhibition of virus induced cytopathic effect after 40 hrs by Cell-Titer-Glo assay
|
influenza A virus
|
820.0
nM
|
|
|
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs by crystal violet staining-based microplate reader analysis
|
influenza A virus
|
16.9
nM
|
|
|
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs by crystal violet staining-based microplate reader analysis
|
Influenza A virus H3N2
|
18.5
nM
|
|
|
Antiviral activity against Influenza A virus PR/8/34 infected in MDCK cells assessed as inhibition of plaque formation treated for 1 hr measured after 2 days by toluidine blue staining-based assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
15.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect at 50 uM incubated for 40 hrs by CellTiter-Glo assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
72.6
%
|
|
|
Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 40 hrs
|
Influenza A virus H3N2
|
1.7
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 40 hrs
|
influenza A virus
|
3.9
ug.mL-1
|
|
|
Antiviral activity against Influenza B virus infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 40 hrs
|
influenza B virus
|
115.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing M2 proton channel S31N mutant infected in MDCK cells assessed as reduction in cytopathic effect after 48 hrs by crystal violet staining-based microscopic analysis
|
Influenza A virus (A/WSN/1933(H1N1))
|
20.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing wild-type M2 proton channel infected in MDCK cells assessed as reduction in cytopathic effect after 48 hrs by crystal violet staining-based microscopic analysis
|
Influenza A virus (A/WSN/1933(H1N1))
|
20.0
nM
|
|
|
Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase using 4-MU-NANA as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by fluorescence assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
0.76
nM
|
|
|
Inhibition of Influenza A virus (A/Hong Kong/498/97(H3N2)) neuraminidase using 4-MU-NANA as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by fluorescence assay
|
Influenza A virus (A/Hong Kong/498/97(H3N2))
|
0.8
nM
|
|
|
Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase H259Y mutant using 4-MU-NANA as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by fluorescence assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
169.3
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) harboring wild type neuraminidase assessed as inhibition of viral replication preincubated for 36 hrs followed by reinfection in new monolayer of MDCK cells every 1 hr for 12 hrs
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
8.26
nM
|
|
|
Antiviral activity against Influenza A virus (A/Hong Kong/498/97(H3N2)) harboring wild type neuraminidase infected in MDCK cells assessed as inhibition of viral replication preincubated for 36 hrs followed by reinfection in new monolayer of MDCK cells every 1 hr for 24 hrs
|
Influenza A virus (A/Hong Kong/498/97(H3N2))
|
14.77
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) harboring neuraminidase H259Y mutant infected in MDCK cells assessed as inhibition of viral replication preincubated for 36 hrs followed by reinfection in new monolayer of MDCK cells every 1 hr for 20 hrs
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
151.7
nM
|
|
|
Antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in plaque formation after 2 days by crystal violet staining based assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
12.0
nM
|
|
|
Synergistic antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in virus-induced cytopathic effect after 44 to 48 hrs in presence of 10:1 3-{[(5-Cyclopropyl-1,2-oxazol-3-yl)methyl]amino}adamantan-1-ol to compound molar ratio by neutral red staining based assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
0.06
nM
|
|
|
Synergistic antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in virus-induced cytopathic effect after 44 to 48 hrs in presence of 5:1 3-{[(5-Cyclopropyl-1,2-oxazol-3-yl)methyl]amino}adamantan-1-ol to compound molar ratio by neutral red staining based assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
0.11
nM
|
|
|
Synergistic antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in virus-induced cytopathic effect after 44 to 48 hrs in presence of 1:1 3-{[(5-Cyclopropyl-1,2-oxazol-3-yl)methyl]amino}adamantan-1-ol to compound molar ratio by neutral red staining based assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
0.42
nM
|
|
|
Synergistic antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in virus-induced cytopathic effect after 44 to 48 hrs in presence of 1:5 3-{[(5-Cyclopropyl-1,2-oxazol-3-yl)methyl]amino}adamantan-1-ol to compound molar ratio by neutral red staining based assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
1.91
nM
|
|
|
Synergistic antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in virus-induced cytopathic effect after 44 to 48 hrs in presence of 1:10 3-{[(5-Cyclopropyl-1,2-oxazol-3-yl)methyl]amino}adamantan-1-ol to compound molar ratio by neutral red staining based assay
|
Influenza A virus (A/WSN/1933(H1N1))
|
1.97
nM
|
|
|
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathicity by MTS assay
|
Influenza A virus (H1N1)
|
200.0
nM
|
|
|
Inhibition of neuraminidase activity in Influenza A virus (A/PR/8/34 (H1N1)) infected in MDCK cells using 4-MU-NANA as substrate pretreated for 30 mins followed by substrate addition measured after 2 hrs by fluorescence assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
77.6
nM
|
|
|
Inhibition of neuraminidase activity in H9N2 A/chicken/Korea/01210/2001 infected in MDCK cells using 4-MU-NANA as substrate pretreated for 30 mins followed by substrate addition measured after 2 hrs by fluorescence assay
|
H9N2 subtype
|
19.1
nM
|
|
|
Antiviral activity against Influenza A virus (A/PR/8/34 (H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by MTT assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
600.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/WSN/33 (H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 48 hrs by microscopic analysis
|
Influenza A virus (A/WSN/1933(H1N1))
|
400.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/PR/8/34 (H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 48 hrs by microscopic analysis
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
130.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Aichi/2/68 (H3N2)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 48 hrs by microscopic analysis
|
Influenza A virus (A/Aichi/2/1968(H3N2))
|
990.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity incubated for 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
3.19
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Victoria/3/1975(H3N2)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity incubated for 48 hrs by SRB assay
|
Influenza A virus (A/Victoria/3/1975(H3N2))
|
12.14
ug.mL-1
|
|
|
Antiviral activity against Influenza B virus (B/Lee/40) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity incubated for 48 hrs by SRB assay
|
Influenza B virus (B/Lee/40)
|
41.87
ug.mL-1
|
|
|
Antiviral activity against Influenza B virus (B/Maryland/1/59) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity incubated for 48 hrs by SRB assay
|
influenza B virus
|
33.17
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 6 hrs before virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
100.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 2 hrs before virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
71.53
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 1 hr before virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
69.82
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated immediately after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
4.12
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 1 hr after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
6.13
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 2 hrs after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
6.05
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 4 hrs after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
7.39
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 7 hrs after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
12.75
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 12 hrs after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
84.26
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity treated 24 hrs after virus infection and measured after 48 hrs by SRB assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
100.0
ug.mL-1
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity at 1 ug/ml treated before virus infection and measured after 48 hrs by SRB assay relative to untreated control
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
25.7
%
|
|
|
Antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect
|
Influenza A virus (A/WSN/1933(H1N1))
|
579.0
nM
|
|
|
Antiviral activity against influenza A virus Hong Kong/8/1968(H3N2) infected in HEK293T cells assessed as inhibition of viral replicon activity incubated for 30 hrs by dual-Glo luciferase assay
|
influenza A virus
|
10.0
nM
|
|
|
Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase at 0.1 to 1000 uM by chemiluminescence based assay
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
1.71
nM
|
|
|
Inhibition of influenza A virus Hong Kong/8/1968(H3N2) neuraminidase at 0.1 to 1000 uM by chemiluminescence based assay
|
influenza A virus
|
0.51
nM
|
|
|
Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase at 10 uM using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay relative to control
|
Influenza A virus (A/Anhui/1/2005(H5N1))
|
91.0
%
|
|
|
Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase at 100 uM using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay relative to control
|
Influenza A virus (A/Anhui/1/2005(H5N1))
|
95.5
%
|
|
|
Inhibition of Influenza A virus A/California/04/2009(H1N1) neuraminidase using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay
|
Influenza A virus (A/California/04/2009(H1N1))
|
2.5
nM
|
|
|
Inhibition of Influenza A virus A/Anhui/1/2013(H7N9) neuraminidase 150 cavity at 10 uM using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay relative to control
|
influenza A virus
|
14.8
nM
|
|
|
Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 30 mins by fluorescence assay
|
Influenza A virus (A/Anhui/1/2005(H5N1))
|
210.0
nM
|
|
|
Antiviral activity against Influenza A virus H3N2 A/Hong Kong/68 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
|
Influenza A virus H3N2
|
3.0
nM
|
|
|
Antiviral activity against Influenza A virus H1N1 A/Jena/8178/09 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
|
Influenza A virus (H1N1)
|
64.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Hong Kong/68(H3N2)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect by crystal violet staining based light-microscopic analysis
|
Influenza A virus (A/Hong Kong/68(H3N2))
|
2.0
nM
|
|
|
Antiviral activity against Influenza A virus A/Udorn/72 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect by crystal violet staining based light-microscopic analysis
|
Influenza A virus (A/udorn/1972(H3N2))
|
1.0
nM
|
|
|
Antiviral activity against Influenza A virus A/WSN/33 H1N1 harboring N31S mutant infected in MDCK cells assessed as reduction in virus-induced cytopathic effect by crystal violet staining based light-microscopic analysis
|
Influenza A virus (A/WSN/1933(H1N1))
|
20.0
nM
|
|
|
Antiviral activity against Influenza A virus A/WSN/33 H1N1 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect by crystal violet staining based light-microscopic analysis
|
Influenza A virus (A/WSN/1933(H1N1))
|
30.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells assessed as reduction in viral titer preincubated with cells for 1 hr followed by viral inoculation and measured after 48 hrs by hemagglutination test
|
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
|
200.0
nM
|
|
|
Inhibition of Influenza A virus (A/California/04/2009 (H1N1) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay
|
Influenza A virus (A/California/04/2009(H1N1))
|
50.0
nM
|
|
|
Inhibition of Influenza A virus (A/Babol/36/2005 (H3N2) neuraminidase expressed by HEK293 cells incubated for 1 hr using 4-MU-NANA substrate by spectrofluorometric assay
|
influenza A virus
|
100.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in human A549 cells assessed as reduction in virus neuraminidase level incubated for 24 hrs by fluorescence based assay
|
Influenza A virus
|
31.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
12.43
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
11.4
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.57
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.57
%
|
|
|
Inhibition of Influenza virus H5N1 neuraminidase
|
H5N1 subtype
|
100.0
nM
|
|
|
Antiviral activity against Influenza A virus (A/Puerto Rico/8/34 (H1N1) infected in MDCK cells assessed as decrease in viral titer preincubated for 1 hr followed by viral infection and cultivated for 48 hrs followed by supernatant transferred to chicken erythrocyte for 1 hr followed by measuring ability to cause positive hemagglutination
|
Influenza A virus
|
0.3
ug.mL-1
|
|
|
Inhibition of Influenza A virus H5N1 neuraminidase
|
H5N1 subtype
|
60.0
nM
|
|
