EcoDrugPlus


Synonyms	(-)-.alpha.-narcotine (-)-narcotine Methoxyhydrastine NSC-5366 Narcotine Narcotinum Noscapine Noscapinum Tusscapine
Status
Molecule Category	Free-form
ATC	R05DA07
UNII	8V32U4AOQU
EPA CompTox	DTXSID4023385


InChI Key	AKNNEGZIBPJZJG-MSOLQXFVSA-N
Smiles	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C
InChI	InChI=1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1

Property Name	Value
Molecular Formula	C22H23NO7
Molecular Weight	413.43
AlogP	2.88
Hydrogen Bond Acceptor	8.0
Number of Rotational Bond	4.0
Polar Surface Area	75.69
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	30.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Structural protein	-	-	579	-	44
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters	-	-	-	-	13.4

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	-	-	-	44
Homo sapiens	-	-	579	-	13.4-50

Resources	Reference
ChEBI	73237
ChEMBL	CHEMBL364713
DrugBank	DB06174
DrugCentral	1973
FDA SRS	8V32U4AOQU
Human Metabolome Database	HMDB0033439
Guide to Pharmacology	10212
KEGG	C09592
PubChem	275196
SureChEMBL	SCHEMBL4559
ZINC	ZINC000019418974

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

NOSCAPINE

Structure

Physicochemical Descriptors

Pharmacology

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