NAFAMOSTAT

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Search structure


Synonyms	Nafamostat
Status
Molecule Category	Free-form
UNII	Y25LQ0H97D
EPA CompTox	DTXSID0048420

Structure


InChI Key	MQQNFDZXWVTQEH-UHFFFAOYSA-N
Smiles	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1
InChI	InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H17N5O2
Molecular Weight	347.38
AlogP	2.65
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	5.0
Number of Rotational Bond	4.0
Polar Surface Area	138.07
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	26.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	490	17-800	-	0.02-410	-
Enzyme Protease Serine protease	490	17-800	-	0.02-410	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	17	-	16	-
Homo sapiens	490	5-800	-	0.02-410	50

Cross References

Resources	Reference
ChEBI	135466
ChEMBL	CHEMBL273264
DrugBank	DB12598
DrugCentral	1867
FDA SRS	Y25LQ0H97D
Guide to Pharmacology	4262
PubChem	4413
SureChEMBL	SCHEMBL135503
ZINC	ZINC000003874467

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025