EcoDrugPlus


Synonyms	Impulsor Midalcipran Milnacipran
Status
Molecule Category	Free-form
ATC	N06AX17
UNII	G56VK1HF36


InChI Key	GJJFMKBJSRMPLA-UHFFFAOYSA-N
Smiles	CCN(CC)C(=O)C1(c2ccccc2)CC1CN
InChI	InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3

Property Name	Value
Molecular Formula	C15H22N2O
Molecular Weight	246.35
AlogP	1.77
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	46.33
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	18.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	0.7943-420	-	6.5-85	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.7943-420	-	6.5-85	-
Rattus norvegicus	-	30-203	-	16-27

Resources	Reference
ChEBI	135005
ChEMBL	CHEMBL259209
DrugBank	DB04896
DrugCentral	1808
FDA SRS	G56VK1HF36
Guide to Pharmacology	7436
SureChEMBL	SCHEMBL114034

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

MILNACIPRAN

Structure

Physicochemical Descriptors

Pharmacology

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