METOPROLOL


Synonyms	(rs)-metoprolol Beatrolol CGP-2175 Dl-metoprolol Lopressidone Metoprolol Metoprolol slow release Seroken Toprol-XL
Status
Molecule Category	Free-form
ATC	C07AB02
UNII	GEB06NHM23
EPA CompTox	DTXSID2023309


InChI Key	IUBSYMUCCVWXPE-UHFFFAOYSA-N
Smiles	COCCc1ccc(OCC(O)CNC(C)C)cc1
InChI	InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3

Property Name	Value
Molecular Formula	C15H25NO3
Molecular Weight	267.37
AlogP	1.61
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	9.0
Polar Surface Area	50.72
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	19.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	14-47.3
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	190-500	14.79-724.44	49-630.96	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	19.8-30.5
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	32.4

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	190-320	14.79-724.44	-	14-47.3
Homo sapiens	-	-	15.85-130	55-220	19.8-38.8
Mus musculus	-	-	-	49	-
Rattus norvegicus	-	-	22.91	398.11-630.96	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia
Sweden
USA

Resources	Reference
ChEBI	6904
ChEMBL	CHEMBL13
DrugBank	DB00264
DrugCentral	1786
FDA SRS	GEB06NHM23
Human Metabolome Database	HMDB0001932
Guide to Pharmacology	553
KEGG	C07202
PharmGKB	PA450480
PubChem	4171
SureChEMBL	SCHEMBL4093

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

METOPROLOL

Structure

Physicochemical Descriptors

Pharmacology

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