MACIMORELIN

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Synonyms
Status
Molecule Category Free-form
ATC V04CD06
UNII 8680B21W73

Structure

InChI Key UJVDJAPJQWZRFR-DHIUTWEWSA-N
Smiles CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O
InChI
InChI=1S/C26H30N6O3/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34)/t22-,23-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H30N6O3
Molecular Weight 474.57
AlogP 1.84
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 6.0
Number of Rotational Bond 10.0
Polar Surface Area 144.9
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 35.0

Pharmacology

Mechanism of Action Action Reference
Ghrelin receptor agonist AGONIST PubMed PubMed Other Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) GRP-related receptor
- 22.9-123 - - -

Target Conservation

Protein: Ghrelin receptor
Description: Growth hormone secretagogue receptor type 1
Organism : Homo sapiens
Q92847 ENSG00000121853

Cross References

Resources Reference
ChEMBL CHEMBL278623
DrugBank DB13074
FDA SRS 8680B21W73
Guide to Pharmacology 9745
PubChem 9804938
SureChEMBL SCHEMBL1984708
ZINC ZINC000001554197
CONTENTS