LONIDAMINE

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Search structure


Synonyms	Doridamina Lonidamine NSC-741419 NSC-758419
Status
Molecule Category	Free-form
ATC	L01XX07
UNII	U78804BIDR
EPA CompTox	DTXSID5020782

Structure


InChI Key	WDRYRZXSPDWGEB-UHFFFAOYSA-N
Smiles	O=C(O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12
InChI	InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H10Cl2N2O2
Molecular Weight	321.16
AlogP	4.09
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	55.12
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	21.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	108.01-129.03

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	108.01-129.03

Cross References

Resources	Reference
ChEBI	50138
ChEMBL	CHEMBL1257030
DrugBank	DB06266
DrugCentral	1598
FDA SRS	U78804BIDR
PubChem	39562
SureChEMBL	SCHEMBL7134
ZINC	ZINC000000001632

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025