LICOGLIFLOZIN

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Synonyms
Status
Molecule Category Free-form
UNII 57J06X6EI0

Structure

InChI Key XFJAMQQAAMJFGB-ZQGJOIPISA-N
Smiles CCc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc2c(c1)OCCO2
InChI
InChI=1S/C23H28O7/c1-2-14-4-5-15(23-22(27)21(26)20(25)19(12-24)30-23)11-16(14)9-13-3-6-17-18(10-13)29-8-7-28-17/h3-6,10-11,19-27H,2,7-9,12H2,1H3/t19-,20-,21+,22-,23+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H28O7
Molecular Weight 416.47
AlogP 1.13
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 5.0
Polar Surface Area 108.61
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 30.0

Pharmacology

Mechanism of Action Action Reference
Sodium/glucose cotransporter 1 inhibitor INHIBITOR PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC05 family of sodium-dependent glucose transporters
- 0.5-0.5 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 0.5-0.5 - - -

Target Conservation

Protein: Sodium/glucose cotransporter 1
Description: Sodium/glucose cotransporter 1
Organism : Homo sapiens
P13866 ENSG00000100170
Protein: Sodium/glucose cotransporter 2
Description: Sodium/glucose cotransporter 2
Organism : Homo sapiens
P31639 ENSG00000140675

Related Entries

Cross References

Resources Reference
ChEMBL CHEMBL4297625
DrugBank DB15048
FDA SRS 57J06X6EI0
Guide to Pharmacology 10654
PubChem 52913524
SureChEMBL SCHEMBL1670083
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