ISTAROXIME


Synonyms	(E,Z)-Istaroxime Istaroxime PST-2744
Status
Molecule Category	UNKNOWN
UNII	W8I9H2TPPL


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	MPYLDWFDPHRTEG-IFVNMTGRSA-N
Smiles	C[C@]12CCC(=NOCCN)C[C@@H]1C(=O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
InChI	InChI=1S/C21H32N2O3/c1-20-7-5-13(23-26-10-9-22)11-17(20)18(24)12-14-15-3-4-19(25)21(15,2)8-6-16(14)20/h14-17H,3-12,22H2,1-2H3/t14-,15-,16-,17+,20+,21-/m0/s1

Mechanism of Action	Action	Reference
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 activator	ACTIVATOR	PubMed PubMed


Protein: Sodium/potassium-transporting ATPase Description: Sodium/potassium-transporting ATPase subunit alpha-1 Organism : Homo sapiens P05023 ENSG00000163399












Protein: Sodium/potassium-transporting ATPase Description: Sodium/potassium-transporting ATPase subunit beta-1 Organism : Homo sapiens P05026 ENSG00000143153












Protein: Sodium/potassium-transporting ATPase Description: Sodium/potassium-transporting ATPase subunit alpha-3 Organism : Homo sapiens P13637 ENSG00000105409











Protein: Sodium/potassium-transporting ATPase Description: Sodium/potassium-transporting ATPase subunit beta-2 Organism : Homo sapiens P14415 ENSG00000129244











Protein: Sodium/potassium-transporting ATPase Description: Sodium/potassium-transporting ATPase subunit alpha-2 Organism : Homo sapiens P50993 ENSG00000018625











Protein: Sodium/potassium-transporting ATPase Description: Sodium/potassium-transporting ATPase subunit alpha-4 Organism : Homo sapiens Q13733 ENSG00000132681

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	200	-	-	-
Transporter Primary active transporter P-type ATPase Hydrogen potassium ATPase	-	200	-	-	-

Assay Description	Organism	Bioactivity	Reference
Inhibitory activity against Na+/K+ ATPase	Canis lupus familiaris	200.0 nM

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