EcoDrugPlus


Synonyms	Hipertene Imidapril Imidapril hcl Imidapril hydrochloride Imidapril monohydrochloride TA 6366 TA-6366 Tanatril
Status
Molecule Category	Free-form
ATC	C09AA16
UNII	BW7H1TJS22
EPA CompTox	DTXSID2048242


InChI Key	KLZWOWYOHUKJIG-BPUTZDHNSA-N
Smiles	CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1C(=O)N(C)C[C@H]1C(=O)O
InChI	InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1

Property Name	Value
Molecular Formula	C20H27N3O6
Molecular Weight	405.45
AlogP	0.88
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	9.0
Polar Surface Area	116.25
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	29.0

Mechanism of Action	Action	Reference
Angiotensin-converting enzyme inhibitor	INHIBITOR	Other

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Rattus norvegicus	-	-	-	-	52-69.8

Resources	Reference
ChEBI	135654
ChEMBL	CHEMBL317094
DrugBank	DB11783
DrugCentral	1424
FDA SRS	BW7H1TJS22
Human Metabolome Database	HMDB0041907
Guide to Pharmacology	6377
PubChem	5464343
SureChEMBL	SCHEMBL34098
ZINC	ZINC000003784427

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

IMIDAPRIL

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References


Protein: Angiotensin-converting enzyme Description: Angiotensin-converting enzyme Organism : Homo sapiens P12821 ENSG00000159640