EcoDrugPlus


Synonyms	Bilxona Dacadis mr Diaglyk Diamicron Diamicron mr Edicil Gliclazide Glimicron Glimil J3.151H NSC-758673 Nazdol mr S-1702 S-852 SE 1702
Status
Molecule Category	Free-form
ATC	A10BB09
UNII	G4PX8C4HKV
EPA CompTox	DTXSID9023095


InChI Key	BOVGTQGAOIONJV-UHFFFAOYSA-N
Smiles	Cc1ccc(S(=O)(=O)NC(=O)NN2CC3CCCC3C2)cc1
InChI	InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)

Property Name	Value
Molecular Formula	C15H21N3O3S
Molecular Weight	323.42
AlogP	1.63
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	78.51
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	22.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	106.3-113.32

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	106.3-113.32
Mus musculus	-	-	-	-	17.4
Rattus norvegicus	-	-	-	-	27.7-135

Resources	Reference
ChEBI	31654
ChEMBL	CHEMBL427216
DrugCentral	1299
FDA SRS	G4PX8C4HKV
Human Metabolome Database	HMDB0015252
PharmGKB	PA10892
PubChem	667431
SureChEMBL	SCHEMBL16387

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

GLICLAZIDE

Structure

Physicochemical Descriptors

Pharmacology

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