Synonyms
Status
Molecule Category Free-form
ATC J05AX27
UNII EW5GL2X7E0

Structure

InChI Key ZCGNOVWYSGBHAU-UHFFFAOYSA-N
Smiles NC(=O)c1nc(F)cnc1O
InChI
InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)

Physicochemical Descriptors

Property Name Value
Molecular Formula C5H4FN3O2
Molecular Weight 157.1
AlogP -0.58
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 89.1
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 11.0

Pharmacology

Mechanism of Action Action Reference
RNA-directed RNA polymerase inhibitor INHIBITOR PMDA PubMed
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
H2N2 subtype
- 48 - - -
Influenza A virus
83-830 160 - - -
Influenza A virus (A/Ann Arbor/6/1960(H2N2))
380 - - - -
Influenza A virus (A/California/05/2009(H1N1))
830 - - - -
Influenza A virus (A/Florida/01/2009(H3N2))
450 - - - -
Influenza A virus (A/New York/18/2009(H1N1))
890 - - - -
Influenza A virus (A/turkey/Minnesota/833/1980(H4N2))
890-960 - - - -
Influenza B virus
- 89 - - -
Influenza B virus (B/Memphis/20/96)
570 - - - -
Influenza C virus
- 44 - - -

Cross References

Resources Reference
ChEBI 134722
ChEMBL CHEMBL221722
DrugBank DB12466
DrugCentral 4887
FDA SRS EW5GL2X7E0
Guide to Pharmacology 11139
PubChem 492405
SureChEMBL SCHEMBL587913
ZINC ZINC000013915654