EcoDrugPlus


Synonyms	(-)-ketamine Esketamine Jnj-54135419 Keta-s Ketamine, (s)- Ketamine, s- Ketaved L-ketamine S-(-)-ketamine S-ketamine
Status
Molecule Category	Free-form
ATC	N01AX14 N06AX27
UNII	50LFG02TXD
EPA CompTox	DTXSID6047810


InChI Key	YQEZLKZALYSWHR-ZDUSSCGKSA-N
Smiles	CN[C@]1(c2ccccc2Cl)CCCCC1=O
InChI	InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3/t13-/m0/s1

Mechanism of Action	Action	Reference
Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor	-	11.4-640	-	300-960	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	108-419	-
Homo sapiens	-	11.4	-	-	-
Rattus norvegicus	-	640	-	300-960	-
Sus scrofa	-	-	-	383	-


Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2D Organism : Homo sapiens O15399 ENSG00000105464












Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 3B Organism : Homo sapiens O60391 ENSG00000116032










Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 1 Organism : Homo sapiens Q05586 ENSG00000176884













Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2A Organism : Homo sapiens Q12879 ENSG00000183454











Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2B Organism : Homo sapiens Q13224 ENSG00000273079











Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2C Organism : Homo sapiens Q14957 ENSG00000161509











Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 3A Organism : Homo sapiens Q8TCU5 ENSG00000198785

ESKETAMINE