ENMD-2076


InChI Key	BLQYVHBZHAISJM-CMDGGOBGSA-N
Smiles	Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1
InChI	InChI=1S/C21H25N7/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26)/b9-8+

Mechanism of Action	Action	Reference
Fibroblast growth factor receptor 3 inhibitor	INHIBITOR	PubMed PubMed Other

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family	-	14-350	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family	-	81-295	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	93	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Fak family	-	55	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	1.86-600	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family	-	10	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	10-20	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	10-36	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	1.86-670	-	-	-


Protein: Serine/threonine-protein kinase Aurora-A Description: Aurora kinase A Organism : Homo sapiens O14965 ENSG00000087586













Protein: Macrophage colony stimulating factor receptor Description: Macrophage colony-stimulating factor 1 receptor Organism : Homo sapiens P07333 ENSG00000182578












Protein: Stem cell growth factor receptor Description: Mast/stem cell growth factor receptor Kit Organism : Homo sapiens P10721 ENSG00000157404












Protein: Fibroblast growth factor receptor 3 Description: Fibroblast growth factor receptor 3 Organism : Homo sapiens P22607 ENSG00000068078











Protein: Vascular endothelial growth factor receptor 2 Description: Vascular endothelial growth factor receptor 2 Organism : Homo sapiens P35968 ENSG00000128052












Protein: Tyrosine-protein kinase receptor FLT3 Description: Receptor-type tyrosine-protein kinase FLT3 Organism : Homo sapiens P36888 ENSG00000122025











Protein: Serine/threonine-protein kinase Aurora-B Description: Aurora kinase B Organism : Homo sapiens Q96GD4 ENSG00000178999

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