EcoDrugPlus


Synonyms	Dutogliptin PHX1149 Phx1149
Status
Molecule Category	Free-form
UNII	38EAO245ZX

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SubStructure

Threshold (%) >= 70


InChI Key	DVJAMEIQRSHVKC-BDAKNGLRSA-N
Smiles	O=C(CN[C@@H]1CCNC1)N1CCC[C@H]1B(O)O
InChI	InChI=1S/C10H20BN3O3/c15-10(7-13-8-3-4-12-6-8)14-5-1-2-9(14)11(16)17/h8-9,12-13,16-17H,1-7H2/t8-,9+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C10H20BN3O3
Molecular Weight	241.1

Mechanism of Action	Action	Reference
Dipeptidyl peptidase IV inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease SC clan Serine protease S9B subfamily	-	23-663	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	23-663	-	-	-

Target Conservation


Protein: Dipeptidyl peptidase IV Description: Dipeptidyl peptidase 4 Organism : Homo sapiens P27487 ENSG00000197635

Cross References

Resources	Reference
ChEMBL	CHEMBL4296719
DrugBank	DB11723
FDA SRS	38EAO245ZX
PubChem	11253490
SureChEMBL	SCHEMBL164106
ZINC	ZINC000169746730

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

DUTOGLIPTIN

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References