DONEPEZIL


InChI Key	ADEBPBSSDYVVLD-UHFFFAOYSA-N
Smiles	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2
InChI	InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	-	-	-	10
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	-	-	-	8.1-87.3
Enzyme Hydrolase	43	1.7-941	8	2.9-640	0-100
Enzyme Oxidoreductase	-	-	-	-	0-0
Enzyme Protease Aspartic protease Aspartic protease AA clan Aspartic protease A1A subfamily	-	169-362	-	-	79.86
Enzyme Transferase	-	5.3	-	-	22
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor epsilon subunit	-	-	-	-	28.5-90.55
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	640	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	350	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	-	-	-	10
Membrane receptor	-	350	-	14.6-14.6	13.8-33.78
Other membrane protein	-	-	-	14.6	-
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	-	-	-	17.8-76

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	4.2-19	-	2.9-2.9	-
Cavia porcellus	-	-	-	14.6	-
Electrophorus electricus	-	6.7-480	-	4.24-56	0-100
Equus caballus	-	4.6-941	-	640-640	24.71-94.38
Homo sapiens	-	2-930	8	7.2-38	0-98
Mus musculus	-	5.7-84	-	-	19-88.99
Rattus norvegicus	-	2-120	-	-	9-58
Torpedo californica	-	12-48	-	-	-

CONTENTS