DEXTROMETHORPHAN HYDROBROMIDE

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Synonyms
Status
Molecule Category Salt-form
UNII 9D2RTI9KYH
Parent Compound:

Structure

InChI Key STTADZBLEUMJRG-IKNOHUQMSA-N
Smiles Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3.O
InChI
InChI=1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H28BrNO2
Molecular Weight 370.33
AlogP 3.38
Hydrogen Bond Acceptor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 12.47
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 20.0

Pharmacology

Mechanism of Action Action Reference
Glutamate [NMDA] receptor subunit epsilon 1 antagonist ANTAGONIST PubMed Wikipedia Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 49.83-78.21
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 49.83-78.21
Plasmodium falciparum
- 794.33 - - -

Target Conservation

Protein: Sigma opioid receptor
Description: Sigma non-opioid intracellular receptor 1
Organism : Homo sapiens
Q99720 ENSG00000147955

Cross References

Resources Reference
ChEBI 4471
ChEMBL CHEMBL1256818
FDA SRS 9D2RTI9KYH
PubChem 5462351
SureChEMBL SCHEMBL121923
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