EcoDrugPlus


Synonyms	(1r,4s)-trans-norsertraline Dasotraline Norsertraline, (1r,4s)-trans- SEP-225289
Status
Molecule Category	Free-form
UNII	4D28EY0L5T
EPA CompTox	DTXSID20217855


InChI Key	SRPXSILJHWNFMK-MEDUHNTESA-N
Smiles	N[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21
InChI	InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16+/m0/s1

Property Name	Value
Molecular Formula	C16H15Cl2N
Molecular Weight	292.21
AlogP	4.92
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	1.0
Polar Surface Area	26.02
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	19.0

Mechanism of Action	Action	Reference
Monoamine transporter inhibitor	INHIBITOR	PubMed

Resources	Reference
ChEMBL	CHEMBL3301595
DrugBank	DB12305
FDA SRS	4D28EY0L5T
Guide to Pharmacology	8308
PubChem	9947999
SureChEMBL	SCHEMBL263142
ZINC	ZINC000002510873

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

DASOTRALINE

Structure

Physicochemical Descriptors

Pharmacology

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