DANIRIXIN

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Search structure


Synonyms	Danirixin GSK-1325756B GSK1325756 GSK1325756B Gsk1325756
Status
Molecule Category	Free-form
UNII	R318PGH5VP

Structure


InChI Key	NGYNBSHYFOFVLS-LBPRGKRZSA-N
Smiles	Cc1c(F)cccc1NC(=O)Nc1ccc(Cl)c(S(=O)(=O)[C@H]2CCCNC2)c1O
InChI	InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H21ClFN3O4S
Molecular Weight	441.91
AlogP	3.66
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	4.0
Polar Surface Area	107.53
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	29.0

Pharmacology

Mechanism of Action	Action	Reference
Interleukin-8 receptor B antagonist	ANTAGONIST	PubMed

Target Conservation


Protein: Interleukin-8 receptor B Description: C-X-C chemokine receptor type 2 Organism : Homo sapiens P25025 ENSG00000180871

Cross References

Resources	Reference
ChEMBL	CHEMBL3039531
DrugBank	DB11922
FDA SRS	R318PGH5VP
Guide to Pharmacology	8500
PubChem	24780598
SureChEMBL	SCHEMBL1198688
ZINC	ZINC000095627831

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025