CYPROTERONE ACETATE


Synonyms	Androcur Androcur 10 Cyprostat Cyproterone Cyproterone acetate Diane NSC-81430 SH 714 SH-714
Status
Molecule Category	Free-form
UNII	4KM2BN5JHF
EPA CompTox	DTXSID5020366


InChI Key	UWFYSQMTEOIJJG-FDTZYFLXSA-N
Smiles	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
InChI	InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1

Mechanism of Action	Action	Reference
Androgen Receptor antagonist	ANTAGONIST	PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Adenosine receptor	-	5-125	-	0.76-636	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	-	23-630.96	-	14	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	103.18

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	103.18
Homo sapiens	-	258.6	-	-	-
Mesocricetus auratus	-	-	-	-	93
Rattus norvegicus	-	5-630.96	-	-	73-90


Protein: Glucocorticoid receptor Description: Glucocorticoid receptor Organism : Homo sapiens P04150 ENSG00000113580











Protein: Progesterone receptor Description: Progesterone receptor Organism : Homo sapiens P06401 ENSG00000082175










Protein: Androgen Receptor Description: Androgen receptor Organism : Homo sapiens P10275 ENSG00000169083

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