CIPROFIBRATE

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Synonyms
Status
Molecule Category Free-form
ATC C10AB08
UNII F8252JGO9S
EPA CompTox DTXSID8020331

Structure

InChI Key KPSRODZRAIWAKH-UHFFFAOYSA-N
Smiles CC(C)(Oc1ccc(C2CC2(Cl)Cl)cc1)C(=O)O
InChI
InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H14Cl2O3
Molecular Weight 289.16
AlogP 3.59
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 46.53
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Mechanism of Action Action Reference
Peroxisome proliferator-activated receptor alpha agonist AGONIST PubMed PubMed PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 1
900-900 - - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
900 - - - -

Target Conservation

Protein: Peroxisome proliferator-activated receptor alpha
Description: Peroxisome proliferator-activated receptor alpha
Organism : Homo sapiens
Q07869 ENSG00000186951

Cross References

Resources Reference
ChEBI 50867
ChEMBL CHEMBL557555
DrugBank DB09064
DrugCentral 658
FDA SRS F8252JGO9S
Guide to Pharmacology 3438
PubChem 2763
SureChEMBL SCHEMBL26870
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