CILNIDIPINE


Synonyms	Atelec Cilnidipine Cinalong FRC-8653 Siscard
Status
Molecule Category	UNKNOWN
ATC	C08CA14
UNII	S85436ZG85
EPA CompTox	DTXSID0046309


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	KJEBULYHNRNJTE-DHZHZOJOSA-N
Smiles	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1
InChI	InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

Mechanism of Action	Action	Reference
Voltage-gated L-type calcium channel blocker	BLOCKER	PubMed


Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1F Organism : Homo sapiens O60840 ENSG00000102001











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1D Organism : Homo sapiens Q01668 ENSG00000157388











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1S Organism : Homo sapiens Q13698 ENSG00000081248











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1C Organism : Homo sapiens Q13936 ENSG00000151067

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated calcium channel	-	1-1	-	-	-

Assay Description	Organism	Bioactivity
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method	Rattus norvegicus	1.1 nM
Analgesic effect in rat following foot-pad injection of formalin at 30 mg/kg, po	Rattus norvegicus	46.0 %
Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus method	Rattus norvegicus	1.1 nM
Inhibition of Voltage-dependent L-type calcium channel in rat thoracic aorta ring	Rattus norvegicus	1.1 nM
Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation at 20 uM after 45 mins by spectrophotometric analysis relative to control	Mus musculus	55.0 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	31.63 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	9.961 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	18.21 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	18.21 %

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