EcoDrugPlus


Synonyms	Bromperidol Impromen NSC-759275 R 11,333 R-11333
Status
Molecule Category	Free-form
ATC	N05AD06
UNII	LYH6F7I22E
EPA CompTox	DTXSID0022690

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SubStructure

Threshold (%) >= 70


InChI Key	RKLNONIVDFXQRX-UHFFFAOYSA-N
Smiles	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1
InChI	InChI=1S/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H23BrFNO2
Molecular Weight	420.32
AlogP	4.53
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	40.54
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	PubMed PubMed PubMed PubMed PubMed PubMed

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295

Cross References

Resources	Reference
ChEBI	31305
ChEMBL	CHEMBL28218
DrugBank	DB12401
DrugCentral	407
FDA SRS	LYH6F7I22E
PubChem	2448
SureChEMBL	SCHEMBL43755
ZINC	ZINC000000601270

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

BROMPERIDOL

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References