EcoDrugPlus


Synonyms	Akineton Akineton- Biperiden Biperidenum KL 373 NSC-759145
Status
Molecule Category	Free-form
ATC	N04AA02
UNII	0FRP6G56LD
EPA CompTox	DTXSID6022680


InChI Key	YSXKPIUOCJLQIE-UHFFFAOYSA-N
Smiles	OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2
InChI	InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2

Property Name	Value
Molecular Formula	C21H29NO
Molecular Weight	311.47
AlogP	3.96
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	23.47
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	23.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	62.9
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	-	-	2.36-32.1	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	10.5	62.9
Homo sapiens	-	-	-	2.36-32.1	-

Resources	Reference
ChEBI	3112
ChEMBL	CHEMBL1101
DrugBank	DB00810
DrugCentral	374
FDA SRS	0FRP6G56LD
Human Metabolome Database	HMDB0014948
Guide to Pharmacology	7128
KEGG	C07941
PharmGKB	PA448626
PubChem	2381
SureChEMBL	SCHEMBL20229360

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

BIPERIDEN

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Pharmacology

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