BENZYDAMINE HYDROCHLORIDE

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Search structure


Synonyms	AF-864 Benzidamine hydrochloride Benzydamine hcl Benzydamine hydrochloride Difflam Difflam-p Lozamine NSC-759276 Tantum
Status
Molecule Category	Salt-form
UNII	K2GI407R4Q
EPA CompTox	DTXSID1045293
Parent Compound:	BENZYDAMINE

Structure


InChI Key	HNNIWKQLJSNAEQ-UHFFFAOYSA-N
Smiles	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12.Cl
InChI	InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H24ClN3O
Molecular Weight	345.87
AlogP	3.42
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	7.0
Polar Surface Area	30.29
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Cross References

Resources	Reference
ChEBI	31266
ChEMBL	CHEMBL1528134
FDA SRS	K2GI407R4Q
PubChem	65464
SureChEMBL	SCHEMBL42644

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025