AZELIRAGON

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Search structure


Synonyms	Azeliragon PF-04494700 TTP-488 TTP448 TTP488
Status
Molecule Category	Free-form
UNII	LPU25F15UQ

Structure


InChI Key	KJNNWYBAOPXVJY-UHFFFAOYSA-N
Smiles	CCCCc1nc(-c2ccc(OCCCN(CC)CC)cc2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1
InChI	InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C32H38ClN3O2
Molecular Weight	532.13
AlogP	8.44
Hydrogen Bond Acceptor	5.0
Number of Rotational Bond	14.0
Polar Surface Area	39.52
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	38.0

Pharmacology

Mechanism of Action	Action	Reference
Advanced glycosylation end product-specific receptor antagonist	ANTAGONIST	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Unclassified protein	-	-	500	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	500	-	-

Target Conservation


Protein: Advanced glycosylation end product-specific receptor Description: Advanced glycosylation end product-specific receptor Organism : Homo sapiens Q15109 ENSG00000204305

Cross References

Resources	Reference
ChEMBL	CHEMBL3989929
DrugBank	DB12689
FDA SRS	LPU25F15UQ
Guide to Pharmacology	8317
PubChem	11180124
SureChEMBL	SCHEMBL1142599
ZINC	ZINC000038336973

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025