VORTIOXETINE HYDROBROMIDE

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Search structure


Trade Names	TRINTELLIX
Synonyms	Lu AA21004 (HBr) Lu aa21004 hbr Lu-aa21004 hydrobromide Trintellix Vortioxetine hydrobromide
Status
Molecule Category	Salt-form
UNII	TKS641KOAY
Parent Compound:	VORTIOXETINE

Structure


InChI Key	VNGRUFUIHGGOOM-UHFFFAOYSA-N
Smiles	Br.Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1
InChI	InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H23BrN2S
Molecular Weight	379.37
AlogP	3.86
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	15.27
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin 1a (5-HT1a) receptor agonist	AGONIST	DailyMed PubMed

Target Conservation


Protein: Serotonin 1a (5-HT1a) receptor Description: 5-hydroxytryptamine receptor 1A Organism : Homo sapiens P08908 ENSG00000178394











Protein: Serotonin transporter Description: Sodium-dependent serotonin transporter Organism : Homo sapiens P31645 ENSG00000108576











Protein: Serotonin 3a (5-HT3a) receptor Description: 5-hydroxytryptamine receptor 3A Organism : Homo sapiens P46098 ENSG00000166736

Cross References

Resources	Reference
ChEBI	76015
ChEMBL	CHEMBL2107387
FDA SRS	TKS641KOAY
PubChem	56843850
SureChEMBL	SCHEMBL237653

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025