TRIPROLIDINE HYDROCHLORIDE

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Search structure


Trade Names	ACTIDIL MYIDYL TRIPROLIDINE HYDROCHLORIDE
Synonyms	Actidil Myidyl NSC-757361 Pro-actidil Triprolidine hcl Triprolidine hydrochloride
Status
Molecule Category	Salt-form
UNII	YAN7R5L890
EPA CompTox	DTXSID0021410

Structure


InChI Key	CUZMOIXUFHOLLN-UMVVUDSKSA-N
Smiles	Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl.O
InChI	InChI=1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H25ClN2O
Molecular Weight	332.88
AlogP	3.92
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	16.13
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	PubMed Wikipedia

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	32265
ChEMBL	CHEMBL3188034
FDA SRS	YAN7R5L890
PubChem	5282442
SureChEMBL	SCHEMBL1140974

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025