TRIMEPRAZINE TARTRATE

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Search structure


Trade Names	TEMARIL TRIMEPRAZINE TARTRATE
Synonyms	Alimemazine hemitartrate Alimemazine tartrate Methylpromazine tartrate NSC-17475 NSC-757358 Panectyl Repeltin Temaril Theralene Trimeprazine hemitartrate Trimeprazine tartrate Vallergan Vallergan fte
Status
Molecule Category	Salt-form
UNII	362NW1LD6Z
EPA CompTox	DTXSID3045560

Structure


InChI Key	AJZJIYUOOJLBAU-UHFFFAOYSA-N
Smiles	CC(CN(C)C)CN1c2ccccc2Sc2ccccc21.CC(CN(C)C)CN1c2ccccc2Sc2ccccc21.O=C(O)C(O)C(O)C(=O)O
InChI	InChI=1S/2C18H22N2S.C4H6O6/c21-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h24-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C40H50N4O6S2
Molecular Weight	747.0
AlogP	4.49
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	6.48
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	PubMed PubMed Wikipedia

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
CAS NUMBER	4330-99-8
ChEMBL	CHEMBL3989885
FDA SRS	362NW1LD6Z
Guide to Pharmacology	7237
KEGG	C07172
PubChem	441236
ZINC	ZINC00896681

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025