EcoDrugPlus


Trade Names	ALLERNAZE ARISTOCORT ARISTOCORT A ARISTOGEL AZMACORT FLUTEX KENALOG KENALOG IN ORABASE KENALOG-10 KENALOG-40 KENALOG-80 KENALOG-H NASACORT NASACORT ALLERGY 24 HOUR NASACORT HFA ORALONE TRIACET TRIACORT TRIAMCINOLONE ACETATE TRIAMCINOLONE ACETONIDE TRIAMCINOLONE ACETONIDE IN ABSORBASE TRIATEX TRIDERM TRIESENCE TRIVARIS TRYMEX ZILRETTA
Synonyms	Adcortyl Adcortyl in orabase Allernaze Aristocort Aristocort a Aristogel Audicort Aureocort Azmacort FX-006 FX006 Flutex Gppe ear dps cap Gppe ear oint Kenacort
Status
Molecule Category	Free-form
UNII	F446C597KA
EPA CompTox	DTXSID6021371

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	YNDXUCZADRHECN-JNQJZLCISA-N
Smiles	CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1
InChI	InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H31FO6
Molecular Weight	434.5
AlogP	2.42
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	93.06
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	31.0

Mechanism of Action	Action	Reference
Glucocorticoid receptor agonist	AGONIST	DailyMed Wikipedia Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	115.53-128.12

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	115.53-128.12
Mus musculus	-	-	-	-	25

Target Conservation


Protein: Glucocorticoid receptor Description: Glucocorticoid receptor Organism : Homo sapiens P04150 ENSG00000113580

Cross References

Resources	Reference
ChEBI	71418
ChEMBL	CHEMBL1504
DrugCentral	2726
FDA SRS	F446C597KA
Guide to Pharmacology	2867
KEGG	C08183
PDB	1TA
PubChem	6436
SureChEMBL	SCHEMBL4689
ZINC	ZINC000003875481

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

TRIAMCINOLONE ACETONIDE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References