THIORIDAZINE HYDROCHLORIDE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII 4WCI67NK8M
EPA CompTox DTXSID9049401
Parent Compound:

Structure

InChI Key NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Smiles CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2.Cl
InChI
InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H27ClN2S2
Molecular Weight 407.05
AlogP 5.89
Hydrogen Bond Acceptor 4.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Mechanism of Action Action Reference
D2-like dopamine receptor antagonist ANTAGONIST ISBN DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 81.91-95.52
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 81.91-95.52

Target Conservation

Protein: Serotonin 2a (5-HT2a) receptor
Description: 5-hydroxytryptamine receptor 2A
Organism : Homo sapiens
P28223 ENSG00000102468
Protein: Serotonin 2c (5-HT2c) receptor
Description: 5-hydroxytryptamine receptor 2C
Organism : Homo sapiens
P28335 ENSG00000147246

Cross References

Resources Reference
ChEBI 48566
ChEMBL CHEMBL1200916
FDA SRS 4WCI67NK8M
Guide to Pharmacology 100
KEGG D00373
PubChem 66062
SureChEMBL SCHEMBL41430
ZINC ZINC01530697
CONTENTS