EcoDrugPlus


Trade Names	KERYDIN
Synonyms	AN-2690 AN2690 Kerydin Tavaborole
Status
Molecule Category	Free-form
ATC	D01AE24
UNII	K124A4EUQ3
EPA CompTox	DTXSID00169888


InChI Key	LFQDNHWZDQTITF-UHFFFAOYSA-N
Smiles	OB1OCc2cc(F)ccc21
InChI	InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2

Property Name	Value
Molecular Formula	C7H6BFO2
Molecular Weight	151.93

Mechanism of Action	Action	Reference
Leucine-tRNA ligase inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Lyase	-	-	-	72-462	-
Enzyme	-	-	-	72-462	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Candida glabrata	-	-	-	72	-
Cryptococcus neoformans	-	-	-	89	-
Homo sapiens	-	-	-	462-462	-
Vibrio cholerae	-	-	-	157-841	-

Resources	Reference
ChEBI	77942
ChEMBL	CHEMBL443052
DrugBank	DB09041
DrugCentral	4877
FDA SRS	K124A4EUQ3
KEGG	D10169
PubChem	11499245
SureChEMBL	SCHEMBL500016
ZINC	ZINC000169990691

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TAVABOROLE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References