TAPENTADOL HYDROCHLORIDE

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Trade Names	NUCYNTA NUCYNTA ER TAPENTADOL HYDROCHLORIDE
Synonyms	BN-200 HYDROCHLORIDE CG-5503 HYDROCHLORIDE CG5503 HYDROCHLORIDE Nucynta Nucynta er Palexia Tapentadol hcl Tapentadol hydrochloride
Status
Molecule Category	Salt-form
UNII	71204KII53
Parent Compound:	TAPENTADOL

Structure


InChI Key	ZELFLGGRLLOERW-YECZQDJWSA-N
Smiles	CC[C@@H](c1cccc(O)c1)[C@@H](C)CN(C)C.Cl
InChI	InChI=1S/C14H23NO.ClH/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12;/h6-9,11,14,16H,5,10H2,1-4H3;1H/t11-,14+;/m0./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H24ClNO
Molecular Weight	257.81
AlogP	3.08
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	23.47
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	16.0

Pharmacology

Mechanism of Action	Action	Reference
Mu opioid receptor agonist	AGONIST	DailyMed

Target Conservation


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Mu opioid receptor Description: Mu-type opioid receptor Organism : Homo sapiens P35372 ENSG00000112038

Cross References

Resources	Reference
ChEMBL	CHEMBL1201777
FDA SRS	71204KII53
KEGG	D06007
PubChem	9838021
SureChEMBL	SCHEMBL17104708
ZINC	ZINC00020783

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025