TAFAMIDIS MEGLUMINE

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Trade Names
Synonyms
Status
Molecule Category Mixture
UNII ZU7CF08A1A

Structure

InChI Key DQJDBUPLRMRBAB-WZTVWXICSA-N
Smiles CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1
InChI
InChI=1S/C14H7Cl2NO3.C7H17NO5/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-6H,(H,18,19);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H24Cl2N2O8
Molecular Weight 503.34
AlogP 4.5
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 63.33
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 20.0

Pharmacology

Mechanism of Action Action Reference
Transthyretin stabiliser STABILISER PubMed

Target Conservation

Protein: Transthyretin
Description: Transthyretin
Organism : Homo sapiens
P02766 ENSG00000118271

Cross References

Resources Reference
ChEBI 79345
ChEMBL CHEMBL2105675
FDA SRS ZU7CF08A1A
PubChem 24970412
SureChEMBL SCHEMBL14783506
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