EcoDrugPlus


Trade Names	PROFENAL
Synonyms	NSC-303611 P-(2-thenoyl)hydratropic acid P-2-thenoylhydratropic acid Profenal R-25,061 R-25061 Racemic suprofen Srendam Sulproltin Suprofen Sutoprofen TN-762 Topalgic
Status
Molecule Category	Free-form
ATC	M01AE07
UNII	988GU2F9PE
EPA CompTox	DTXSID5045469

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Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	MDKGKXOCJGEUJW-UHFFFAOYSA-N
Smiles	CC(C(=O)O)c1ccc(C(=O)c2cccs2)cc1
InChI	InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H12O3S
Molecular Weight	260.31
AlogP	3.17
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	54.37
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	560	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	96.21-108.54

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	96.21-108.54
Homo sapiens	-	560	-	-	0
Rattus norvegicus	-	-	-	-	-0.7-16.9

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Cross References

Resources	Reference
ChEBI	9362
ChEMBL	CHEMBL956
DrugBank	DB00870
DrugCentral	2546
FDA SRS	988GU2F9PE
Human Metabolome Database	HMDB0015008
Guide to Pharmacology	7298
KEGG	C07320
PharmGKB	PA451569
PubChem	5359
SureChEMBL	SCHEMBL23792
ZINC	ZINC00057504

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

SUPROFEN

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References