|
Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C
|
None
|
300.0
nM
|
|
|
Inhibitory activity against Human carbonic anhydrase II
|
None
|
300.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)
|
None
|
300.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (CA2)
|
None
|
300.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II
|
None
|
300.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
None
|
300.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
|
None
|
300.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method
|
None
|
300.0
nM
|
|
|
Inhibition of human carbonic anhydrase II (hCA II)
|
None
|
300.0
nM
|
|
|
Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.
|
None
|
294.0
nM
|
|
|
Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX
|
None
|
294.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.
|
None
|
294.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method
|
None
|
294.0
nM
|
|
|
Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
|
None
|
32.0
nM
|
|
|
Inhibition of cloned isozyme, human carbonic anhydrase II
|
None
|
300.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase II
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase IX
|
Homo sapiens
|
294.0
nM
|
|
|
Ki value against human carbonic anhydrase II
|
Homo sapiens
|
240.0
nM
|
|
|
Ki value against human carbonic anhydrase VII
|
Homo sapiens
|
70.0
nM
|
|
|
Ratio against Carbonic anhydrase II to Carbonic anhydrase IX
|
Homo sapiens
|
1.02
Ratio
|
|
|
Ki value against murine carbonic anhydrase XIII
|
Mus musculus
|
32.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCAII)
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
|
Methanosarcina thermophila
|
250.0
nM
|
|
|
Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibitory activity against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition constant against human recombinant carbonic anhydrase II
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibition constant against human recombinant carbonic anhydrase IX catalytic domain
|
Homo sapiens
|
294.0
nM
|
|
|
Zone of inhibition of Escherichia coli at compound concentration of 40 mg/mL
|
Escherichia coli
|
16.5
mm
|
|
|
Zone of inhibition of Escherichia coli at compound concentration of 80 mg/mL
|
Escherichia coli
|
18.0
mm
|
|
|
Zone of inhibition of Bacillus subtilis at compound concentration of 40 mg/mL
|
Bacillus subtilis
|
10.5
mm
|
|
|
Zone of inhibition of Bacillus subtilis at compound concentration of 80 mg/mL
|
Bacillus subtilis
|
11.5
mm
|
|
|
Zone of inhibition of Escherichia coli at compound concentration of 160 mg/mL
|
Escherichia coli
|
20.5
mm
|
|
|
Zone of inhibition of Salmonella typhae at compound concentration of 40 mg/mL
|
Salmonella enterica subsp. enterica serovar Typhi
|
7.0
mm
|
|
|
Zone of inhibition of Salmonella typhae at compound concentration of 80 mg/mL
|
Salmonella enterica subsp. enterica serovar Typhi
|
7.5
mm
|
|
|
Zone of inhibition of Bacillus subtilis at compound concentration of 160 mg/mL
|
Bacillus subtilis
|
13.0
mm
|
|
|
Zone of inhibition of Salmonella typhae at compound concentration of 160 mg/mL
|
Salmonella enterica subsp. enterica serovar Typhi
|
7.5
mm
|
|
|
Zone of inhibition of Staphylococcus aureus at compound concentration of 40 mg/mL
|
Staphylococcus aureus
|
20.5
mm
|
|
|
Zone of inhibition of Staphylococcus aureus at compound concentration of 80 mg/mL
|
Staphylococcus aureus
|
22.5
mm
|
|
|
Zone of inhibition of Pseudomonas aeruginosa at compound concentration of 40 mg/mL
|
Pseudomonas aeruginosa
|
13.5
mm
|
|
|
Zone of inhibition of Pseudomonas aeruginosa at compound concentration of 80 mg/mL
|
Pseudomonas aeruginosa
|
15.5
mm
|
|
|
Zone of inhibition of Staphylococcus aureus at compound concentration of 160 mg/mL
|
Staphylococcus aureus
|
25.0
mm
|
|
|
Zone of inhibition of Pseudomonas aeruginosa at compound concentration of 160 mg/mL
|
Pseudomonas aeruginosa
|
17.5
mm
|
|
|
Inhibitory activity against human Carbonic anhydrase II (hCA II)
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibitory activity against human Carbonic anhydrase IX (hCA IX)
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibitory activity against human Carbonic anhydrase XII (hCA XII)
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibitory activity against human recombinant cytosolic CA2
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay
|
Helicobacter pylori
|
454.0
nM
|
|
|
Inhibition of human recombinant CA2
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant CA
|
Helicobacter pylori
|
431.0
nM
|
|
|
Inhibition of full length human recombinant CA VI
|
Homo sapiens
|
941.0
nM
|
|
|
Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of catalytic domain of human recombinant CA IX
|
Homo sapiens
|
238.0
nM
|
|
|
Inhibition of human CYP2C9 assessed as (S)-Flurbiprofen hydroxylation
|
Homo sapiens
|
-17.8
%
|
|
|
Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
941.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay
|
Homo sapiens
|
238.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Cryptococcus neoformans recombinant Can2 by stopped-flow CO2 hydration assay
|
Cryptococcus neoformans
|
765.0
nM
|
|
|
Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
240.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
|
Stylophora pistillata
|
364.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
988.0
nM
|
|
|
Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
941.0
nM
|
|
|
Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
70.0
nM
|
|
|
Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
238.0
nM
|
|
|
Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
32.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydrase assay method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method
|
Homo sapiens
|
240.0
nM
|
|
|
Binding affinity to bovine carbonic anhydrase 2
|
Bos taurus
|
851.14
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
941.0
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
364.0
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
300.0
nM
|
|
|
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
|
Cryptococcus neoformans
|
770.0
nM
|
|
|
Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human full length cytosolic isoform of carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human recombinant catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human wild type carbonic anhydrase 2 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
363.0
nM
|
|
|
Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
296.0
nM
|
|
|
Inhibition of human wild type carbonic anhydrase 2 Leu204Ser mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
251.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Cryptococcus neoformans
|
765.0
nM
|
|
|
Inhibition of GST-tagged Malassezia globosa ATCC 96807/CBS 7966 MG-CA expressed in Escherichia coli BL21(DE3) cells preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Malassezia globosa CBS 7966
|
245.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Vibrio cholerae
|
471.0
nM
|
|
|
Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells after 48 hr by MTT assay
|
Homo sapiens
|
90.0
nM
|
|
|
Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by MTT assay
|
Homo sapiens
|
80.0
nM
|
|
|
Cytotoxicity against Homo sapiens (human) K562 cells after 48 hr by MTT assay
|
Homo sapiens
|
200.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Sulfurihydrogenibium yellowstonense
|
803.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Helicobacter pylori
|
316.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibition of human recombinant CA9 using 4-nitrophenylacetate as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
290.0
nM
|
|
|
Inhibition of human recombinant CA2 using 4-nitrophenylacetate as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
260.0
nM
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
113.76
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
155.79
%
|
|
|
Inhibition of human CA13 preincubated for 15 mins by stopped-flow CO2 hydration method
|
Homo sapiens
|
35.0
nM
|
|
|
Inhibition of human CA12 preincubated for 15 mins by stopped-flow CO2 hydration method
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human CA9 preincubated for 15 mins by stopped-flow CO2 hydration method
|
Homo sapiens
|
238.0
nM
|
|
|
Inhibition of human CA7 preincubated for 15 mins by stopped-flow CO2 hydration method
|
Homo sapiens
|
70.0
nM
|
|
|
Inhibition of human CA6 preincubated for 15 mins by stopped-flow CO2 hydration method
|
Homo sapiens
|
941.0
nM
|
|
|
Inhibition of human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Thalassiosira weissflogii
|
181.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
893.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-CA CAM by stopped flow CO2 hydration assay
|
Leishmania donovani chagasi
|
250.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
893.0
nM
|
|
|
Inhibition of human recombinant cytosolic human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-12 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
37.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
|
Homo sapiens
|
300.0
nM
|
|
|
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-1 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
946.0
nM
|
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
277.0
nM
|
|
|
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
715.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis Gamma-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
893.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Methanosarcina thermophila
|
250.0
nM
|
|
|
Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Porphyromonas gingivalis
|
893.0
nM
|
|
|
Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay
|
Nostoc commune
|
488.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Anopheles gambiae
|
862.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay
|
Nostoc commune
|
488.0
nM
|
|
|
Inhibition of Methanosarcina thermophila recombinant gamma carbonic anhydrase by stopped flow CO2 hydrase assay method
|
Methanosarcina thermophila
|
250.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of cytosolic carbonic anhydrase 2 esterase activity isolated from human serum using 4-nitrophenylacetate as substrate measured over 3 mins by spectrophotometric analysis
|
Homo sapiens
|
628.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Sulfurihydrogenibium yellowstonense
|
652.0
nM
|
|
|
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Thiomicrospira crunogena XCL-2
|
628.0
nM
|
|
|
Inhibition of Vibrio cholerae beta-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
447.0
nM
|
|
|
Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
471.0
nM
|
|
|
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
893.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Nostoc commune
|
488.0
nM
|
|
|
Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Colwellia psychrerythraea
|
867.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Vibrio cholerae beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
447.0
nM
|
|
|
Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay
|
Enterobacter sp.
|
583.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
447.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
471.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
95.3
nM
|
|
|
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of Vibrio cholerae Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Vibrio cholerae
|
95.3
nM
|
|
|
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-2 preincubated for 10 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-9 preincubated for 10 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
294.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-12 preincubated for 10 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
37.0
nM
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
53.84
%
|
|
|
Anti-inflammatory activity in Wistar rat assessed as inhibition of kaolin paw edema at 50 mg/kg, po dosed 1 hr before kaolin injection and measured 4 hrs after kaolin injection relative to untreated control
|
Rattus norvegicus
|
10.0
%
|
|
|
Inhibition of AChE (unknown origin) at 0.5 mM using acetylcholine iodide as substrate by Ellman method relative to untreated control
|
Homo sapiens
|
10.19
%
|
|
|
Inhibition of BuChE (unknown origin) at 0.5 mM using butyrylthiocholine bromide as substrate by Ellman method relative to untreated control
|
Homo sapiens
|
5.19
%
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
240.0
nM
|
|
|
Inhibition of recombinant Plasmodium falciparum eta-carbonic anhydrase (181 to 538 residues) expressed in Escherichia coli artic express (DE3) preincubated for 15 mins by stop flow CO2 hydrase assay
|
Plasmodium falciparum
|
808.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
14.84
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
16.04
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.73
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.04
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.73
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.04
%
|
|
|
Inhibition of Vibrio cholerae beta carbonic anhydrase pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
68.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay
|
Homo sapiens
|
256.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay
|
Homo sapiens
|
298.0
nM
|
|
