EcoDrugPlus


Trade Names	ZAGAM
Synonyms	AT-4140 CI-978 NSC-759641 Spara Sparfloxacin Zagam
Status
Molecule Category	Free-form
ATC	J01MA09
UNII	Q90AGA787L
EPA CompTox	DTXSID9023590


InChI Key	DZZWHBIBMUVIIW-DTORHVGOSA-N
Smiles	C[C@@H]1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C[C@H](C)N1
InChI	InChI=1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+

Property Name	Value
Molecular Formula	C19H22F2N4O3
Molecular Weight	392.41
AlogP	2.08
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	3.0
Polar Surface Area	100.59
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	28.0

Mechanism of Action	Action	Reference
Bacterial DNA gyrase inhibitor	INHIBITOR	FDA

Resources	Reference
ChEBI	9212
ChEMBL	CHEMBL850
DrugBank	DB01208
DrugCentral	2466
FDA SRS	Q90AGA787L
Human Metabolome Database	HMDB0015339
Guide to Pharmacology	10860
KEGG	C07662
PharmGKB	PA451472
PubChem	60464
SureChEMBL	SCHEMBL41311
ZINC	ZINC000000538362

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

SPARFLOXACIN

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