SODIUM OXYBATE

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Search structure


Trade Names	SODIUM OXYBATE XYREM
Synonyms	.gamma.-hydroxybutyrate sodium salt Catabate NSC-84223 Oxybate sodium Sodium oxybat Sodium oxybate Sodium oxybutyrate WY-3478 Xyrem
Status
Molecule Category	Salt-form
ATC	N01AX11 N07XX04
UNII	7G33012534
EPA CompTox	DTXSID3048940

Structure


InChI Key	XYGBKMMCQDZQOZ-UHFFFAOYSA-M
Smiles	O=C([O-])CCCO.[Na+]
InChI	InChI=1S/C4H8O3.Na/c5-3-1-2-4(6)7;/h5H,1-3H2,(H,6,7);/q;+1/p-1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C4H7NaO3
Molecular Weight	126.09
AlogP	-0.16
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	57.53
Molecular species	ACID
Aromatic Rings	0.0
Heavy Atoms	7.0

Pharmacology

Mechanism of Action	Action	Reference
GABA-B receptor agonist	AGONIST	PubMed DailyMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	66
Rattus norvegicus	-	-	-	-	60

Target Conservation


Protein: GABA-B receptor Description: Gamma-aminobutyric acid type B receptor subunit 2 Organism : Homo sapiens O75899 ENSG00000136928












Protein: GABA-B receptor Description: Gamma-aminobutyric acid type B receptor subunit 1 Organism : Homo sapiens Q9UBS5 ENSG00000204681

Cross References

Resources	Reference
ChEMBL	CHEMBL1200682
DrugBank	DB09072
FDA SRS	7G33012534
PubChem	23663870
SureChEMBL	SCHEMBL61823

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025