EcoDrugPlus


Trade Names	MERIDIA
Synonyms	BTS 54524 BTS-54524 Meridia NSC-758928 Sibutramine hcl Sibutramine hydrochloride Sibutramine hydrochloride civ Sibutramine hydrochloride hydrate Sibutramine hydrochloride monohydrate
Status
Molecule Category	Salt-form
UNII	OGM0YHD1WF
Parent Compound:	SIBUTRAMINE

Trade Names

MERIDIA

Synonyms

BTS 54524

BTS-54524

Meridia

NSC-758928

Sibutramine hcl

Sibutramine hydrochloride

Sibutramine hydrochloride civ

Sibutramine hydrochloride hydrate

Sibutramine hydrochloride monohydrate

Status

Molecule Category

Salt-form

UNII

OGM0YHD1WF

Parent Compound:

SIBUTRAMINE


InChI Key	KFNNPQDSPLWLCX-UHFFFAOYSA-N
Smiles	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1.Cl.O
InChI	InChI=1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

InChI Key

KFNNPQDSPLWLCX-UHFFFAOYSA-N

Smiles

CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1.Cl.O

InChI

InChI=1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

Property Name	Value
Molecular Formula	C17H29Cl2NO
Molecular Weight	334.33
AlogP	4.74
Hydrogen Bond Acceptor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	3.24
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	19.0

Property Name

Value

Molecular Formula

C17H29Cl2NO

Molecular Weight

334.33

AlogP

4.74

Hydrogen Bond Acceptor

1.0

Number of Rotational Bond

5.0

Polar Surface Area

3.24

Molecular species

BASE

Aromatic Rings

1.0

Heavy Atoms

19.0

Mechanism of Action	Action	Reference
Monoamine transporter inhibitor	INHIBITOR	FDA

Mechanism of Action

Action

Reference

Monoamine transporter inhibitor

INHIBITOR

FDA

Resources	Reference
ChEMBL	CHEMBL3989830
FDA SRS	OGM0YHD1WF
Guide to Pharmacology	2586
KEGG	C07247
PubChem	64765
SureChEMBL	SCHEMBL42301
ZINC	ZINC00531272

Resources

Reference

ChEMBL

CHEMBL3989830

FDA SRS

OGM0YHD1WF

Guide to Pharmacology

KEGG

PubChem

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

SIBUTRAMINE HYDROCHLORIDE

Structure

Physicochemical Descriptors

Pharmacology

Cross References